乳腺癌RCL、TAOK1、14-3-3 zeta、ZNF706蛋白表达的临床病理意义

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Abstract Objective: To detect the expression of RCL, TAOK1, 14-3-3 zeta and ZNF706 proteins in the breast cancer tissue, and to analyse and discuss the relationship between the expression of each protein and its clinical, as well as pathological relevance. Methods: Immunohistochemistry was used to detect the protein expression of RCL, TAOK1, 14-3-3 zeta and ZNF706 in 60 cases of breast cancer tissues, then the relationship between the expression of each protein in the cancer tissues and the tissues’ pathological grading, tumor size, metastatic status, and prognosis were evaluated by mathematic statistic methods. Results: RCL, TAOK1, 14-3-3 zeta and ZNF706 proteins were expressed in all of the breast cancer tissues, and the expression level were significantly higher than that in para-carcinoma tissues (P<0.05). The elevated expression of RCL was related to the tumor size, pathological grading and Ki67 (P<0.05). The expression of TAOK1 was related to the expression of ER and HER2 (P<0.05). The expression of 14-3-3 zeta was also related to ER (P<0.05). The expression of ZNF706 was related to lymphatic metastasis and ER (P<0.05). Conclusion: RCL, TAOK1, 14-3-3 zeta and ZNF706 proteins are high expressed in breast cancer tissues than that in normal tissues. The elevated expression of RCL is related to the tumor size, pathological grading and Ki67. The expression of TAOK1 is related to the expression of ER and HER2. The expression of 14-3-3 zeta is also related to ER. And the expression of ZNF706 is related to lymphatic metastasis and ER. The protein expression of RCL, TAOK1, 14-3-3 zeta and ZNF706 are detected in breast cancer tissues can help us determine the degree of tumor malignancy and predict the prognosis of the patients.

Key words： RCL TAOK1 14-3-3 zeta ZNF706 breast neoplasms

Received: 17 February 2014

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	Articles by authors
	LING Ren1
	LING Jin2
	NI Xinghao3
	XUE Hongyan4
	SHI Hongqi5
	CHEN Zhonghua1

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2014/V44/I11/817

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