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| Clinical application of 18F-FDG-PET/CT combined with magnetic resonance imaging in predicting preoperative T and N staging of colorectal cancer |
| ZU Liang, WANG Zufei, CHEN Weiyue,WU Xulu, XIAO Yangrui, JI Jiansong |
| Department of Radiology, Key Laboratory of Imaging Diagnosis and Minimally Invasive Research, Lishui Central Hospital the Affiliated Fifth Hospital of Wenzhou Medical University, Lishui 323000,China |
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| Cite this article: |
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ZU Liang,WANG Zufei,CHEN Weiyue, et al. Clinical application of 18F-FDG-PET/CT combined with magnetic resonance imaging in predicting preoperative T and N staging of colorectal cancer[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(12): 968-973.
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Abstract Objective: To explore the clinical application value of 18F-FDG-PET/CT combined with magnetic resonance imaging (MRI) in predicting preoperative T and N staging of colorectal cancer. Methods:Patients who had surgical resection for colorectal cancer in our hospital were retrospectively enrolled from January 2015 to October 2019. All patients underwent 18F-FDG-PET/CT and MRI scans within two weeks before the operation, with postoperative pathological results taken as the gold standard. The consistency test was performed between test results and pathology, and chi-square test was used to compare the accuracy, sensitivity,and specificity of combined and single examination. Results: A total of 92 patients were enrolled in the study,including 55 males and 37 females, with the average age of (64.7±10.6)years. The study showed that the T staging results of the combined examination had a strong consistency with the pathology (Kappa value was 0.888). The accuracy (93.48%) was higher than that of PET/CT alone (69.57%), which showed statistically significant difference (P<0.001), but had no obvious advantage compared with MRI alone (P=0.090). Meanwhile,the N staging results of the combined examination had a strong consistency with the pathology (Kappa=0.804),and the accuracy (88.04%) was higher than that of MRI (67.39%) and PET/CT (75.00%), with significant difference (P=0.001 and 0.023). Furthermore, the combined examination had better, the accuracy (93.48%)and specificity (93.75%) in the diagnosis of lymph node metastasis than MRI (P=0.001 and 0.002) and PET/CT alone (P=0.037 and 0.037). Conclusion: Preoperative 18F-FDG-PET/CT combined with MRI has high diagnostic efficiency for preoperative T and N staging of colorectal cancer, especially in the evaluation of N staging and lymph node metastasis, which is of strong clinical application value.
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Received: 23 August 2021
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