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| Correlation between quality parameter based on thin-section CT and clinical symptoms of COVID-19 pneumonia |
| FU Gangze, TAO Jiejie, SUN Houchang, YANG Yunjun, WANG Meihao |
| Department of Radiology,the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China |
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| Cite this article: |
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FU Gangze,TAO Jiejie,SUN Houchang, et al. Correlation between quality parameter based on thin-section CT and clinical symptoms of COVID-19 pneumonia[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(9): 719-723.
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Abstract Objective: To calculate the lung quality of CT lesions in patients with COVID-19 pneumonia,and explore its correlation with early clinical features and laboratory indicators. Methods: The DICOM format of thin-section CT of 48 patients with COVID-19 during January 19, 2020 to February 31, 2020 were collected and transmitted to the post-processing software for segmentation of lesions by artificial intelligence. The volume and average density of the lesion were obtained, and the mass of the diseased lung calculated. The correlation between the quality of diseased lungs and gender, age, body temperature, onset time and laboratory tests was explored, and the quality difference among groups with different clinical characteristics was compared. Results: Forty-eight patients, aged (45.2±16.5)years, 26 males and 22 females, had a median onset of 3 days. The lung quality was significantly correlated with the patient’s body temperature, fever days, and C-reactive protein values (P<0.05),with r values of 0.373, 0.360, and 0.713, respectively. The lung quality in the moderate or high fever group was 65.7 (41.8, 101.7)g, which was significantly larger than that in the low fever group [10.0 (3.1, 49.3)g] or the nonfever group [5.5 (1.0, 16.0)g]. The quality in patients with initial CT scan≥5 days from illness onset was 45.7(16.4, 86.3)g, which was significantly higher than patients≤4 days from illness onset [10.0 (2.6, 39.3)g]; the quality in patients with high C-reactive protein was 45.4 (11.3, 88.4)g, significantly higher than patients with normal Creactive protein [4.0 (1.2, 14.2)g]. All differences were statistically significant (P<0.05). Conclusion: The quality of the diseased lung is significantly correlated with the clinical symptoms and laboratory indicators of COVID-19 patients, which can be used as one of the effective CT quantitative parameters reflecting the severity of viral pneumonia.
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Received: 07 January 2021
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