美蓝染色联合术中超声探查在乳腺癌前哨淋巴结活检中的应用

doi:10.3969/j.issn.2095-9400.2021.06.011

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Abstract Objective: To investigate the clinical practicability and advantages of methylene blue staining combined with intraoperative ultrasound exploration in improving the removal rate and positive detection rate of sentinel lymph node (SLN) during breast cancer surgery. Methods: From Jan. 2020 to Dec. 2020, 145 consecutive
cases with clinical axillary lymph node-negative early breast cancer were enrolled. All patients underwent sentinel lymph node biopsy (SLNB) through methylene blue staining combined with intraoperative ultrasound detection. Intraoperative frozen and postoperative paraffin pathological examinations were performed to SLN, with
respectively calculation of the blue-stained SLN and the suspicious SLN detected by ultrasound as well as the number of metastatic lymph nodes contained in each. Results: All 145 patients were blue stained and successfully underwent SLNB. The detection rate of positive SLN by methylene blue staining was 21.7% (114/526), and the detection rate of positive SLN combined with intraoperative ultrasound detection was 26.2% (155/591), with significant difference (P<0.05); the detection rate of macrometastasis SLN by methylene blue staining was 7.0% (8/114), and the detection rate of macrometastasis SLN combined with intraoperative ultrasound exploration was 18.7% (29/155), with significant difference (P<0.05). Conclusion: The use of methylene blue staining has a certain rate of missed diagnosis in breast cancer SLNB. However, combined with intraoperative ultrasound exploration, it is of clinical significance by remarkably increasing the SLN resection rate and positive detection rate.

Key words： breast cancer sentinel lymph node biopsy methylene blue ultrasound, intraoperative

Received: 23 February 2021

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	YANG Qing
	XIANG Yingying
	SHEN Yanyan
	ZHENG Jinying
	ZHAO Yaxin

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https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2021.06.011 OR https://xb.wmu.edu.cn/EN/Y2021/V51/I6/487

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