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| Promotion of romotes skeletal muscle function recovery in hysterectomy patients by Shenmai injection |
| ZHU Meizhen1, PAN Yafei2, CHEN Lei1, WANG Liangrong1, LIN Li’na1 |
| 1.Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China; 2.Department of Anesthesiology, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310000, China |
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| Cite this article: |
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ZHU Meizhen,PAN Yafei,CHEN Lei, et al. Promotion of romotes skeletal muscle function recovery in hysterectomy patients by Shenmai injection[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(4): 315-318.
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Abstract Objective: To investigate the effect of Shenmai injection pretreatment on the levels of cytokines in abdominal drainage and skeletal muscle function in patients undergoing laparoscopic hysterectomy. Methods: Sixty-six patients undergoing laparoscopic hysterectomy were randomly divided as the control group (C group) and the Shenmai group (SM group). The patients in SM group received intravenous administration of Shenmai injection 0.6 mL/kg before skin incision, while the same amount of saline was given instead in C Group. The grip strength, muscle endurance, and inflammatory cytokines levels in abdominal drainage fluid were measured before
surgery as baselines and 4 h, 1, 2 days post-operation as well. The occurrence of nausea, vomiting and other adverse events were also documented. Results: Compared with C group, the declines in grip strength and muscle endurance in SM group were significantly attenuated in each time point (P<0.05). However, grip strength and muscle endurance were decreased in both groups, compared with baseline values (P<0.05). The levels of IL-6 and TNF-α in the abdominal drainage fluid of SM group at 4 hours post-operation were significantly lower than those of group C (P<0.05), and the level of IL-6 in the drainage fluid was negatively correlated with grip work (P<0.05). There was no significant difference in adverse events between the the groups (P>0.05). Conclusion: Pretreatment with Shenmai injection 0.6 mL/kg could reduce the production of inflammatory cytokines and thus promote the recovery of skeletal muscle function in patients undergoing laparoscopic hysterectomy.
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Received: 29 October 2020
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参考文献：
[1] JENSEN M B, HOUBORG K B, NORAGER C B, et al. Postoperative changes in fatigue, physical function and body composition: an analysis of the amalgamated data from five randomized trials on patients undergoing colorectal surgery [J]. Colorectal Dis, 2011, 13(5): 588-593.
[2] ZARGAR-SHOSHTARI K, HILL A G. Postoperative fatigue: a review[J]. World J Surg, 2009, 33(4): 738-745.
[3] BAUTMANS I, NJEMINI R, DE BACKER J, et al. Surgeryinduced inflammation in relation to age, muscle endurance, and self-perceived fatigue[J]. J Gerontol A Biol Sci Med Sci, 2010, 65(3): 266-273.
[4] TAN S, ZHOU F, LI N, et al. Anti-fatigue effect of ginsenoside Rb1 on postoperative fatigue syndrome induced by major small intestinal resection in rat[J]. Biol Pharm Bull, 2013, 36(10): 1634-1639.
[5] HWANG Y P, JEONG H G. Ginsenoside Rb1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt/Nrf2-dependent pathway in human dopaminergic cells[J]. Toxicol Appl Pharmacol, 2010, 242(1): 18-28.
[6] ZHU J, JIANG Y, WU L, et al. Suppression of local inflammation contributes to the neuroprotective effect of ginsenoside Rb1 in rats with cerebral ischemia[J]. Neuroscience, 2012, 202: 342-351.
[7] O’LEARY D P, WANG J H, COTTER T G, et al. Less stress, more success? Oncological implications of surgeryinduced oxidative stress[J]. Gut, 2013, 62(3): 461-470.
[8] LUSTGARTEN M S, JANG Y C, LIU Y, et al. MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging[J]. Aging cell, 2011, 10(3): 493-505.
[9] DECHERNEY A H, BACHMANN G, ISAACSON K, et al. Postoperative fatigue negatively impacts the daily lives of patients recovering from hysterectomy[J]. Obstet Gynecol, 2002, 99(1): 51-57.
[10] LAUSZUS F F, KALLFA E, MADSEN M R. Fatigue and physical function after hysterectomy measured by SF-36, ergometer, and dynamometer[J]. Arch Gynecol Obstet, 2016, 294(1): 95-101.
[11] ZHUANG C L, MAO X Y, LIU S, et al. Ginsenoside Rb1 improves postoperative fatigue syndrome by reducing skeletal muscle oxidative stress through activation of the PI3K/Akt/Nrf2 pathway in aged rats[J]. Eur J Pharmacol, 2014, 740: 480-487.
[12] PADDISON J S, BOOTH R J, FUCHS D, et al. Peritoneal inflammation and fatigue experiences following colorectal surgery: a pilot study[J]. Psychoneuroendocrinology, 2008, 33(4): 446-454.
[13] MAIER S F, GOEHLER L E, FLESHNER M, et al. The role of the vagus nerve in cytokine-to-brain communication[J]. Ann N Y Acad Sci, 1998, 840: 289-300.
[14] DANTZER R, KONSMAN J P, BLUTHE R M, et al. Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent?[J]. Auton Neurosci, 2000, 85(1-3): 60-65.
[15] BADIA J M, WHAWELL S A, SCOTT-COOMBES D M, et al. Peritoneal and systemic cytokine response to laparotomy[J]. Br J Surg, 1996, 83(3): 347-348.
[16] ZARGAR-SHOSHTARI K, SAMMOUR T, KAHOKEHR A, et al. Randomized clinical trial of the effect of g l u c o c o r t i c o i d s o n p e r i t o n e a l i n f l amma t i o n a n d postoperative recovery after colectomy[J]. Br J Surg, 2009,96(11): 1253-1261. |
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