超早期干预对脑瘫高风险儿神经和运动发育的影响

doi:10.3969/j.issn.2095-9400.2021.04.008

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Abstract Objective: To explore the effect of ultra-early intervention on the improvement of nerve and motor development in infants at high risk of cerebral palsy. Methods: From January 2017 to January 2018, 53 newborns, who were born in Xiasha District-Zhejiang Hospital of TCM and diagnosed as infants at high risk of cerebral palsy, were enrolled in the observation group, 46 infants at high risk of cerebral palsy (3-5 months old), who came to Zhejiang Rehabilitation Hospital in the same period, were enrolled in the control group, and 50 healthy newborns, who were born in Xiasha District-Zhejiang Hospital of TCM in the same period, were enrolled in the healthy group. The children in the observation group were intervened after diagnosis (within 7 days after birth), and the Neurodevelopmental therapy (NDT) was mainly used. The intervention measures and procedures used in the control group were the same as those of the observation group. The scores of development quotient (DQ), Gesell development scale (adaptability/the gross motor/fine motor/language/personal social contact) were observed among the three groups at each month, and were compared at 24 months of age between the observation group and the control group in the proportion of patients who reached normalization, progressed to cerebral palsy and lagged in overall development. Results: The scores of DQ in each functional area, total DQ, Gesell development scale (adaptability/the gross motor/fine motor/language/personal social contact) of the observation group were significantly lower than those of the healthy group (P<0.05) at baseline and 3 months old, and the scores of DQ in each functional area, total DQ, Gesell development scale (adaptability/the gross motor/fine motor/language/personal social contact) of the three groups were statistically significant (P<0.05) at 6, 12, 18 and 24 months old. The scores in the observation group were significantly higher than those in the control group (P<0.05). The rate of normalization in observation group was higher than in control group, and the incidence of cerebral palsy and general underdevelopment was lower than that of the control group, but there was no significant difference between the two groups (P>0.05). Conclusion: For infants at high risk of cerebral palsy, ultra-early diagnosis and intervention can improve the normalization rate of high-risk infants with cerebral palsy and reduce the incidence of cerebral palsy which is of significant clinical benefit.

Key words： cerebral palsy newborn ultra-early intervention neurodevelopment motor development

Received: 26 August 2020

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	WANG Chen
	ZHANG Chao
	PAN Shaohua

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https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2021.04.008 OR https://xb.wmu.edu.cn/EN/Y2021/V51/I4/298

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