|
|
|
| Obserration on the effect of narrow-band ultraviolet b combined with desloratadine in the treatment of generalized eczema and dermatitis |
Department of Dermatovenereology, the First Affiliated Hospital of Wenzhou Medical University, Institute of Venero-dermatology, Wenzhou, 325015
|
|
| Cite this article: |
|
XUAN Xuan,WU Lingjian,LI Bingxu. Obserration on the effect of narrow-band ultraviolet b combined with desloratadine in the treatment of generalized eczema and dermatitis[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(10): 737-739.
|
|
|
Abstract Objective: To evaluate the clinical efficacy and safety of narrow-band ultraviolet b combined with desloratadine in the treatment of generalized eczema and dermatitis. Methods: Non-randomized concurrent control trial was used to assign 114 patients in UV-treatment group (n=57) and glucocorticoid-treatment group (n=57). Patients in UV-treatment group received the therapy of narrow-band ultraviolet b combined with oral desloratadine. Patients in glucocorticoid-treatment group were topically applied with mometasone furoate ointment combined with oral desloratadine. In UV-treatment group, symptom/sign scores were evaluated at the 2th, 4th and 8th week’s end of the treatment. In glucocorticoid-treatment group, symptom/sign scores were evaluated at the 2th and 4th week’s end of the treatment. Scores and effective rates were observed after the treatment. Results: After 2 weeks of treatment, the median score of glucocorticoid-treatment group (3) and UV-treatment group (2) had significant difference (P<0.05); the efficient rate of UV-treatment group (12.3%) and hormones-treatment group (38.6%) had significant difference (P<0.05). After 4 weeks of treatment, the median score of glucocorticoid-treatment group (5) and UV-treatment group (4) had no significant difference (P>0.05); the efficient rate of UV-treatment group (59.6%) and glucocorticoid-treatment group (56.1%) had no significant difference (P>0.05). In UV-treatment group, the median score had significant difference at the 2th (2), 4th (4) and 8th (6) week’s end of the treatment; the efficient rate had significant difference at the 2th (12.3%), 4th (59.6%) and 8th (84.2%) week’s end of the treatment. Conclusion: The therapy of narrow-band ultraviolet b is safe and effective in the treatment of patients with generalized eczema and dermatitis.
|
|
Received: 10 March 2014
|
| |
|
|
|
[1]赵辨. 中国临床皮肤病学[M]. 南京: 江苏科学技术出版社, 2012: 717-741.
[2]李亚婷, 史同新, 秦智芬. 窄谱中波紫外线治疗银屑病临床观察[J]. 临床皮肤科杂志, 2012, 41(12): 763-764.
[3]杨宝琦, 赵娜, 张福仁. 银屑病光疗和光化学疗法的研究进展[J]. 中华皮肤科杂志, 2005, 38(3): 195-197.
[4]贾雪松, 钟文英, 王娟, 等. 窄谱中波紫外线治疗对寻常性银屑病患者血清TNF-α, IL-10水平的影响[J]. 中国皮肤性病学杂志, 2012, 25(9): 678-680.
[5]Johnson-Huang LM, Suárez-Fariñas M, Sullivan-Whalen M, et al. Effective narrow-band UVB radiation therapy sup-presses the IL-23/IL-17 axis in normalized psoriasis plaques[J]. J Invest Dermatol, 2010, 130(11): 2654-2663.
[6]Boniface K, Guignouard E, Pedretti N, et al. A role for T cell-derived interleukin 22 in psoriatic skin inflammation[J]. Clin Exp Immunol, 2007, 150(3): 407-415.
[7]Walters IB, Ozawa M, Cardinale I, et a1. Narrowband (312-nm) UV-B suppresses interferon gamma and in terleukin(IL) 12 and increases IL-4 transcripts: differential regulation of cytokines at the single-cell level[J]. Arch Dermatol, 2003, 139(2): 155-161.
[8]Rivard J, Lim HW. Ultraviolet phototherapy for pruritus[J].Dermatol Ther, 2005, 18(4): 344-354. |
| [1] |
. [J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2018, 48(6): 458-462. |
|
|
|
|
2014, Vol. 44 
