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| A comparative study of CD31 expression level and image spatial heterogeneity between benign and malignant pulmonary nodules |
| HONG Junjie1, LIU Bole1, CHEN Yao2, TANG Kun1, XUE Beihui1, WU Sunjie1, ZHENG Xiangwu1 |
| 1.Department of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China; 2.Department of Pathology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China |
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| Cite this article: |
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HONG Junjie,LIU Bole,CHEN Yao, et al. A comparative study of CD31 expression level and image spatial heterogeneity between benign and malignant pulmonary nodules[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(2): 142-145.
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Abstract Objective: To analyze the spatial heterogeneity of microvascular density (MVD) in benign and malignant pulmonary nodules based on CD31 expression level. Methods: Thirty-five cases of paraffin tissue specimens were collected after wedges resection of pulmonary nodules, including 7 cases of squamous cell carcinoma, 23 cases of adenocarcinoma and 5 cases of inflammatory nodules. Immunohistochemistry was used to detect the expression level of CD31, a microvascular marker in the proximal and distal pulmonary nodules. Paired t-test and independent sample t-test were used to analyze the difference of CD31 expression level between intragroup
and inter-group. Results: CD31 expression in the proximal/distal part of the 30 malignant nodules was 19.2±8.6 and 13.3±6.8, respectively, with significant difference (P<0.05). The CD31 expression in the proximal/distal part of 5 benign nodules was 28.2±10.0 and 26.8±3.0, respectively, without statistical difference (P>0.05).The comparison between benign and malignant groups showed that the expression of CD31 at the distal part of benign nodules was higher than that of malignant nodules (P<0.05). No significant difference was found in the expression of CD31 at the proximal part of benign and malignant nodules (P>0.05). Conclusion: Based on CD31
expression level, difference exists in MVD of proximal/distal part between benign and malignant pulmonary nodules, which provides pathological basis for the spatial heterogeneity of benign/malignant pulmonary nodules.
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Received: 21 July 2020
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