温州地区急性白血病儿童CYP3A5基因多态性研究#br#

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Abstract Objective: To study the relationship of CYP3A5-6986A/G polymorphism and acute leukemia in Han population of southern Chinese. Methods: The methods of polymerase chain reaction-restriction fragment length polymorphism and PCR sequence were used, the polymorphism of the CYP3A5 gene was detected in both 119 acute leukemia patients and 106 control subjects. Results: ①The differences in the distribution of genotype of CYP3A5-6986A/G between the patients and the controls were significant. ②The genetic frequency of G allele in ALL and in AML were all higher than that in controls. ③The results by gender stratification showed that the boy individuals with CYP3A5 variant genotype were more susceptible to childhood leukemia with a 2.65-fold increased risk compared to the individuals with wild genotype. ④There was no variation of CYP3A5-6986A/G polymorphism on acute leukemia patients between Wenzhou and Suzhou area. Conclusion: The CYP3A5 genetic polymorphism may be associated with the susceptibility of acute leukemia in Han population of male southern Chinese.

Key words： leukemia children genetic polymorphism susceptibility cytochrome P450-3A5

Received: 27 November 2013

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	HUANG Zhen
	CHEN Min
	ZENG Weiwei
	LI Yuan.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2014/V44/I10/733

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