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| Clinical phenotyping of obstructive sleep apnea-hypopnea syndrome based on excessive daytime sleepiness |
| SHAO Chuan, FANG Qing, CHEN Yinyu, TU Jinjing |
| Department of Respiratory and Critical Care Medicine,Ningbo Medical Center Lihuili Hospital, Ningbo 315040, China |
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| Cite this article: |
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SHAO Chuan,FANG Qing,CHEN Yinyu, et al. Clinical phenotyping of obstructive sleep apnea-hypopnea syndrome based on excessive daytime sleepiness[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(2): 118-122.
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Abstract Objective: To investigate the clinical characteristics in patients with obstructive sleep apneahypopnea syndrome (OSAHS) and excessive daytime sleepiness (EDS) and the possible risk factors of EDS.Methods: A total of 413 OSAHS patients were assigned to the EDS or the non-EDS group according to the Epworth sleepiness scores. Univariate and multivariate analysis was conducted on clinical features and polysomnographic variables. Results: The incidences of gasping/choking (51.8% vs. 36%), morning headache(25.5% vs. 11%), and memory loss (72.3% vs. 54.8%) were higher in the EDS group. A higher percentage of patients in the EDS group complained life (50.4% vs. 35.3%), work (47.5% vs. 19.5%) and commute (24.8% vs.9.6%) disturbance. The micro-arousal index (MAI) (50.72±21.20 vs. 39.43±19.50), apnea hypopnea index(AHI) (56.18±22.74 vs. 35.21±23.04), the longest time of apnea [(66.60±29.24)s vs. (55.05±25.01)s], oxygen desaturation index (ODI) (57.89±24.10 vs. 36.34±24.12) and the saturation impair time below 90% (SIT90)(14.5% vs. 4.3%) were higher or longer in the EDS group. The nadir [(63.96±16.85)% vs.(74.04±12.27)%] and mean nocturnal SpO2 [(91.25±4.55)% vs. (93.92±2.62)%] was lower in the EDS group. Multivariate analysis showed morning headache [OR(95%CI)=3.809(1.704-8.514)], memory loss [OR(95%CI)=1.914(1.002-3.654)],work [OR(95%CI)=3.445(1.772-6.698)] and commute disturbances [OR(95%CI)=2.468(1.061-5.738)] were independently associated with EDS, and the MAI [OR(95%CI)=1.030(1.015-1.045)], AHI [OR(95%CI)=1.043(1.006-1.081)] and SIT90 [OR(95%CI)=1.038(1.018-1.058)] were independent risk factors of EDS.Conclusion: OSAHS patients with EDS have more comorbid symptoms than those without EDS. Sleep fragmentation, AHI and nocturnal hypoxia are independent risk factors for EDS.
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Received: 14 May 2020
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