心踝血管指数、年龄及其交互作用与颈动脉粥样硬化的关联分析#br#

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Abstract Objective: To explore the correlation between arteriosclerosis early identification and cardio-ankle vascular index (CAVI), age and their interaction. Methods: A cross-sectional study was conducted to explore this association in a Chinese population consisting of 328 participants enrolled from the ordinary medical checkup population in the 1st affiliated hospital of Anhui Medical University. CAVI was measured in duplicate and carotid ultrasound detection was performed in a quiet environment by well-trained physicians. Generalized linear models were conducted to assess the correlation. Results: Prevalence of carotid arteriosclerosis for participants with high, medium and low CAVI score were 90.9%, 57.0% and 19.8%, respectively. After adjusted for the potential confounding factors such as age, gender, body mass index (BMI), low density lipoprotein cholesterol (LDL), fasting plasma glucose (FPG), blood pressure (BP), creatinine, education, occupation, psychological tension, cigarette smoking and alcohol drinking, CAVI positively associated with the risk for carotid arteriosclerosis. Compared with participants in the lowest tertile of CAVI (5.15~7.40), those in the medium (7.41~8.65) and highest (8.66~13.60) had the OR (95% CI) of 2.2 (1.0, 4.9) and 4.4 (1.5, 13.3) for developing carotid arteriosclerosis (P=0.007). Compared with low age groups, the risks of future carotid arteriosclerosis for participants with medium and high age increased 7.1 and 51.3 folds, respectively. CAVI and age were all positively associated with the future carotid arteriosclerosis risk (Trend test P<0.001). Compared to subjects with low age and low CAVI, the risks of future carotid arteriosclerosis for participants with low age and high CAVI, high age and low CAVI, high age and high CAVI increased 6.6, 17.3 and 57.1 folds, respectively. Conclusion: CAVI is an independent risk factor of carotid arteriosclerosis, can be used for the prediction of future carotid arteriosclerosis developing and has a statistical significantly interaction with age in predicting the future risk of carotid arteriosclerosis.

Key words： cardio-ankle vascular index carotid artery disease cardiovascular disease cross-sectional study

Received: 18 September 2013

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	HUANG Xi1
	LI Ping1
	ZHANG Qin1
	ZHUGE Zhangming1
	HU Huaqing2
	CUI Huan3
	RUAN Jichen1
	MAO Guangyun4.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2014/V44/I10/727

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