丹皮酚对血管性认知障碍小鼠认知功能的保护作用

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Abstract Objective: To investigate the effects of paeonol on cognitive dysfunctions and hippocampal neuronal injury of vascular cognitive impairment (VCI) mice. Methods: Sixty C57BL/6 mice were randomly divided into sham opertated group, the VCI group and the paeonol treated groups (low, medium and high dose). The VCI models were dupilicated by the bilateral common carotid artery occlusion (2VO). The cognitive impairments were observed by Morris water maze. The contents of MDA, SOD and NO in hippocampus were determined spectrometrically. The hippocampal neuron injuries in the CA1 region were detected by nissle staining. Results: VCI induced the decreased cognitive function and neuron injury in the hippocampal CA1 region (P<0.01). And MDA and NO contents were significantly increased, whereas SOD activity was dramatically decreased after VCI (P<0.01). Compared with VCI model goup, the medium and high dose of paeonol treatment significantly improved cognitive impairments and reduced pathological changes in hippocampal CA1 region (P<0.05, P<0.01). In additon, the medium and high dose of paeonol treatment markedly improved SOD activity, decreased MDA and NO contents in hippocampus (P<0.05, P<0.01). Conclusion: Paeonol can improve cognitive impairments and neuronal injury in VCI mice, which may be related to the increased antioxidative ability of brain tissue.

Key words： cognitive impairment, vascular antioxidant hippocampus paeonol mice

Received: 09 April 2014

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	WANG Hao1
	GENG Zhaoming2
	GUO Dengjun1
	HU Zhiwei1
	WANG Baichen1.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2014/V44/I10/708

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