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| Investigation and analysis of RBC-irregular antibodies in hospitalized patients |
| CHEN Bile1, CAI Xuejiao1, YE Yincai1, LIN Shuangnyu1, ZHUO Shenglin2, XIE Zuoting1 |
| 1.Department of Blood Transfusion,the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China; 2.Department of Blood Transfusion, Yongjia County People’s Hospital, Wenzhou 325100, China |
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| Cite this article: |
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CHEN Bile,CAI Xuejiao,YE Yincai, et al. Investigation and analysis of RBC-irregular antibodies in hospitalized patients[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2020, 50(11): 915-918.
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Abstract Objective: To investigate and analyze the positive rate, distribution characteristics, specificity and immunoglobulin types of RBC-irregular antibodies in hospitalized patients. Methods: Samples of all patients in our hospital between Nov. 2017 and Oct. 2019 were collected, with irregular samples of erythrocyte blood groups screened for a statistical analysis of positive antibodies, the positive rate, distribution characteristics,specificity and immunoglobulin types of antibodies. Results: Total positive rate of RBC-irregular antibodies in hospitalized patients was 0.29%(834/287 030); the positive rate of antibody in male patients and female patients was 0.20% and 0.38% respectively. There was statistically difference between groups (P<0.05). RBC-irregular antibodies distribution had the following characteristics: the antibody-positive composition ratio of female patients was 66.99%(558/834), while that of male patients was 33.01%(276/834). The proportion of antibody-positive was 72.22%(403/588) in women with history of pregnancy but no history of blood transfusion, and that was 5.38%(30/588) in women with no history of pregnancy but history of blood transfusion; the antibody-positive ratio of female patients with history of both pregnancy and blood transfusion was 19.35%(108/588), while the antibodypositive ratio of female patients without history of either pregnancy or blood transfusion was 3.05%(17/588).RBC-irregular antibodies specificity showed that 54.80%(457/834) of antibody specificity could be determined,of which the Rh blood group system had the highest proportion of anti-E antibodies, accounting for 27.58%.Immunoglobulin types of RBC-irregular antibodies were mainly IgG antibodies, accounting for 72.90%(632/834).Conclusion: In patients with RBC-irregular antibodies positive in this hospital were mainly female patients with pregnancy history, and the specificity of irregular antibodies was most commonly IgG anti-E antibodies.
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Received: 28 January 2020
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. [J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(11): 943-946, 封三. |
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