不同肾小球滤过率评估公式在2型糖尿病患者中的适用性

doi:10.3969/j.issn.2095-9400.2020.09.009

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Abstract Objective: To evaluate the different glomerular filtration rate assessment formulas in type 2 diabetic patients. Methods: The data of 322 patients with type 2 diabetes mellitus were analyzed retrospectively, the glomerular filtration rate calculated by 24-hour creatine clearance rate was rGFR, eGFR was calculated by C-G formula, simplified MDRD formula, and the improved MDRD China formula and CKD-EPI formula, to compare the accuracy, accuracy, deviation, ROCAUC of each eGFR, and hierarchical analysis at different ages and glycosylated hemoglobin. Results: The correlation coefficient between GFR estimated by CKD-EPI formula and rGFR was the highest, r=0.788. The P15 and P30 of CKD-EPI formula were the highest, which are 48.1% and 73.6%, respectively. Bland-Altman diagram showed minimum deviation between simplified MDRD formula and rGFR, CKD-EPI formula had the highest accuracy. The area under ROC curve of MDRDC formula and CKD-EPI formula in the diagnosis of chronic renal insufficiency was equal and the largest. In the group of age≥60 years old and the group of 18<age<60 years old, the correlation of CKD-EPI formula was the best, P30 and P50 were the highest, and the highest accuracy. CKD-EPI formula had the best P30 and P50, the highest accuracy in different glycosylated hemoglobin. Conclusion: The CKD-EPI formula was most suitable for the estimation of GFR in Chinese patients with type 2 diabetes mellitus at the same time under different ages and glycosylated hemoglobin.

Key words： type 2 diabetes mellitus glomerular filtration rate glomerular filtration rate estimation equations CKD-EPI formula

Received: 20 May 2019

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	Zhu Simeng
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https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2020.09.009 OR https://xb.wmu.edu.cn/EN/Y2020/V50/I9/733

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