脐血AFABP、瘦素与非妊娠期糖尿病巨大儿发生的相关性分析

doi:10.3969/j.issn.2095-9400.2020.09.003

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Abstract Objective: To investigate the correlation of AFABP and leptin in umbilical cord blood with non-GDM macrosomia. Methods: A case-control study was performed. Newborns were selected, with 46 macrosomia and 46 normal-birth-weight, in the Obstetric Department of the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University. A self-designed questionnaire was used to collect maternal and fetal baseline information. The umbilical cord blood concentration of AFABP and leptin was measured by ELISA and RIA, respectively. Logistic regression analysis was used to analyze the influencing factors of non-GDM macrosomia. Results: There was no difference in cord blood AFABP concentration between the two groups, and the leptin concentration in macrosomia cord blood was significantly higher than that of control group (P<0.05). Stratified analysis found that in the higher gestational layer (gestational age>39) and excessive gestational weight gain layer, AFABP concentration in macrosomia cord blood was significantly lower than that of the control group (P<0.05); the leptin concentration in macrosomia cord blood was significantly higher than that of the control group in the male fetal layer, lower gestational age layer (gestational age≤39) and normal gestational weight gain layer(P<0.05). Multivariable logistic regression analysis showed that the lower AFABP concentration in umbilical cord blood could increase the risk of non-GDM macrosomia (OR=3.792, 95%CI: 1.266~11.359, P<0.05), the occurrence of non-GDM macrosomia was also influenced by fetal gender, gestational age and gestational weight gain. Conclusion: Lower AFABP concentration in umbilical cord blood may increase the risk of non-GDM macrosomia. Further studies are required to elucidate its molecular mechanism.

Key words： adipocyte fatty acid binding protein leptin macrosomia umbilical bleeding

Received: 30 April 2020

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	YE Yan
	DING Miaomiao
	WANG Yuhuan
	YAN Hongtao
	YANG Xinjun

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https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2020.09.003 OR https://xb.wmu.edu.cn/EN/Y2020/V50/I9/700

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