影响男性阻塞性睡眠呼吸暂停综合征患者阴茎勃起功能障碍的因素

doi:10.3969/j.issn.2095-9400.2020.06.013

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Abstract Objective: To investigate the factors that cause penile erectile dysfunction (ED) in male patients with obstructive sleep apnea syndrome (OSAS) and its possible mechanism. Methods: As measured by polysomnography (PSG) and simultaneous nocturnal penile erection (NPT), of 90 male OSAS patients 48 patients were with ED (ED group) and 42 patients without ED (OSAS group). The concentrations of serum testosterone (TT), prolactin (PRL), estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), nitric oxide (no) and nitric oxide synthetase (NOS) were measured in the next morning. Results: Compared between the two groups, there was significant difference in BMI (P<0.05), but not in sex hormone levels (P>0.05). However, the levels of NO and NOS in the ED group were significantly lower than those in the OSAS group (P<0.05), and logistic regression analysis showed that obesity, TT and NO were the main factors affecting erectile dysfunction in male OSAS (all P<0.05). Obesity was a risk factor, while TT and NO were protective factors. Conclusion: The occurrence of ED in male OSAS patients may be related to obesity, TT and NO. It was speculated that the level of NO in OSAS patients may play a key role in maintaining their erectile function.

Key words： obstructive sleep apnea syndrome erectile dysfunction obesity sex hormone nitric oxide

Received: 02 November 2019

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https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2020.06.013 OR https://xb.wmu.edu.cn/EN/Y2020/V50/I6/493

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