连花清瘟对急性肺栓塞家兔的疗效

doi:10.3969/j.issn.2095-9400.2020.06.010

Abstract
Figure/Table
References (0)
Related Citation (4)

Download: PDF (1610 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To investigate the effect of Lianhuaqingwen (LHQW) on reducing inflammatory cytokines in a rabbit model of acute pulmonary embolism (APE). Methods: Rabbits were randomly divided into sham operation group, model group and LHQW group, with 10 rabbits in each group. In the model group and the LHQW group autologous blood clots were repeatedly injected into the main pulmonary artery of the rabbits to establish the APE model. After the model was established, the LHQW group was intragastrically administered with LHQW 0.42 g/kg; the sham operation group and the model group were intragastrically administered with an equal amount of 0.9% NaCl solution. The changes in arterial blood gas, hemodynamics and inflammatory factors at different time points were compared among the three groups. Results: Compared with the model group, PaO2 was significantly higher at 1 and 8 hours post LHQW treatment (P<0.05). Compared with the model group, the MPAP in the LHQW group was significantly reduced at 1, 2, 4, and 8 hours after treatment (P<0.05); compared with the model group, the MAP in the LHQW group was significantly increased at 1, 2, 4, and 8 hours after treatment (P<0.05). The levels of cTnI, NT-proBNP, TNF-α, IL-6 and IL-1β in the LHQW group were significantly lower than those in the model group at 1, 2, 4 and 8 hours after treatment (P<0.05). HE staining showed that the accumulation of neutrophils in the pulmonary embolism tissue of the LHQW group was significantly lower than that of the model group (274.6±96.0 vs. 111.5±38.1, P=0.003). Conclusion: LHQW is helpful in reducing the level of systemic inflammation and myocardial injury while improving arterial blood gas and hemodynamics in APE rabbits. It has therapeutic effect on APE to a certain extent.

Key words： Lianhuaqingwen acute pulmonary embolism inflammatory cytokines arterial blood gas hemodynamics

Received: 03 August 2019

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	CHEN Zhili
	CHEN Yuxi
	QIU Xianke

URL:

https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2020.06.010 OR https://xb.wmu.edu.cn/EN/Y2020/V50/I6/480

[1] RIGHINI M, ROBERT-EBADI H, LE GAL G. Diagnosis of acute pulmonary embolism[J]. J Thromb Haemost, 2017, 15(7): 1251-1261.
[2] STEWART L K, NORDENHOLZ K E, COURTNEY M, et al. Comparison of acute and convalescent biomarkers of inflammation in patients with acute pulmonary embolism treated with systemic fibrinolysis vs. placebo[J]. Blood Coagul Fibrinolysis, 2017, 28(8): 675-680.
[3] 干瑶, 范绍辉, 陈艳琳, 等. 急性呼吸窘迫综合征小鼠肺组织MIP-2、IL-8 mRNA表达及支气管肺泡灌洗液中性粒细胞百分比观察[J]. 山东医药, 2019, 59(3): 43-46.
[4] 毕丹, 孙云波, 宋联强, 等. 连花清瘟胶囊化学成分研究(I)[J]. 中草药, 2018, 49(4): 795-800.
[5] DING Y, ZENG L, LI R, et al. The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function[J]. BMC Complement Altern Med, 2017, 17(1): 130.
[6] 夏敬文, 陈小东, 张静, 等. 连花清瘟胶囊对慢性阻塞性肺病治疗作用的研究[J]. 复旦学报(医学版), 2008, 35(3): 441-444.
[7] 陈之力, 缪心军, 陈玉熹. 伐地那非对急性肺血栓栓塞症家兔的治疗效果研究[J]. 中国现代医生, 2013, 51(25): 10-13.
[8] 陈团营, 朱珊, 边红恩, 等. 连花清瘟颗粒对小儿肺炎支原体肺炎肺功能指标、血清炎症因子水平影响及疗效分析[J]. 中华中医药学刊, 2018, 36(11): 2713-2715.
[9] 白容, 杨超. 胸腺五肽联合连花清瘟胶囊对AECOPD患者的疗效及其对免疫功能的影响[J]. 检验医学与临床, 2018, 15(5): 592-595.
[10] KONSTANTINIDES S V, TORBICKI A, AGNELLI G, et al.
2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism: the task force for the diagnosis and management of acute pulmonary embolism of the european society of cardiology (ESC)endorsed by the European Respiratory Society (ERS)[J]. Eur Heart J, 2014, 21(16): 1301-1336.
[11] YU D, WANG Y, YU Y, et al. Acute beneficial effects of sodium nitroprusside in a rabbit model of massive pulmonary embolism associated with circulatory shock[J]. Am J Pathol, 2018, 188(8): 1768-1778.
[12] ZHAO L B, JIA Z Y, LU G D, et al. Establishment of a canine model of acute pulmonary embolism with definite right ventricular dysfunction through introduced autologous blood clots[J]. Thromb Res, 2015, 135(4): 727-732.
[13] SISTA A K, KUO W T, SCHIEBLER M, et al. Stratification, imaging, and management of acute massive and submassive pulmonary embolism[J]. Radiology, 2017, 284(1): 5-24.
[14] 陈淳, 林建伟, 李国平, 等. 白藜芦醇调控大鼠急性肺栓塞后肺动脉高压及MCP-1表达的机制研究[J]. 中国药理学通报, 2017, 33(10): 1436-1441.
[15] ROY P M, CORSI D J, CARRIER M, et al. Net clinical benefit of hospitalization versus outpatient management of patients with acute pulmonary embolism[J]. J Thromb Haemost, 2017, 15(4): 685-694.