子宫内膜息肉摘除术后两种内膜准备方案临床结局的比较

doi:10.3969/j.issn.2095-9400.2020.06.008

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Abstract Objective: To investigate the potential of gonadotropin-releasing hormone agonist down-regulated hormone replacement therapy (GnRH-a+HRT) and hormone replacement therapy (HRT) for patients after endometrial polypectomy. Methods: This study analyzed 109 patients with endometrial polypectomy in three months who underwent frozen-thawed blastocyst transfer within three months after endometrial polypectomy at Reproductive Center of the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University from July 2018 to July 2019. The basic conditions of the patients, blastocyst transfer outcomes and pregnancy outcomes between two groups were compared. Results: A total of 56 patients were enrolled in the HRT group and one of them canceled the transplant and 53 patients were enrolled in the GnRH-a+HRT group. There was no significant differences between the two groups of patients in their basic conditions. Though the HRT group had lower rate of the specific infertility factor than the GnRH-a+HRT group, there was no statistically difference. No difference was found in the conditons of endometrial and blastocysts transplants between the two gruops. Compared to the HRT group, the positive rate of HCG, the rate of clinical pregnancy, the rate of embroy implantation was higher in GnRH-a+HRT group but no significant difference were found. There were no difference between the groups in the early abortion rate and multiple pregnancy. Conclusion: Both GnRH-a+HRT and HRT could achieve great pregnancy outcomes and each has its own advantages and disadvantages. For patients with endometriosis, adenomyosis, intramural myomas, polycystic ovary syndrome or hydrosalpinxs, it is suggested that the GnRH-a+HRT be considered the first choice.

Key words： gonadotropin-releasing hormone agonist hormone replacement therapy endometrial polyps

Received: 16 October 2019

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	Articles by authors
	XU Jialing
	SU Weijue
	CHEN Yufeng
	FU Yanghua
	XI Haitao
	ZHAO Junzhao

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https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2020.06.008 OR https://xb.wmu.edu.cn/EN/Y2020/V50/I6/471

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