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| The role of dual time point PET/CT imaging in diagnosis of solitary pulmonary nodule with low metabolism |
| Department of PET/CT, Raiology Imaging Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015 |
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LIN Jie,TANG Kun,YIN Weiwei, et al. The role of dual time point PET/CT imaging in diagnosis of solitary pulmonary nodule with low metabolism[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(9): 704-.
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Abstract Objective: To evaluate the role of dual time point 18F-FDG PET/CT imaging in diagnosis of solitary pulmonary nodule (SPN) with low metabolism. Methods: During August 2011 to June 2013, forty-five patients confirmed with SPN and SUVmax≤2.5 at early PET/CT imaging were retrospectively analysed (male 27, female 18, mean age 59.71±11.42 years). All patients were performed with early and delayed PET/CT imaging at 60 min and 120 min after intravenous injection respectively. The eraly and delayed maximum standardized uptake value (SUVmax) of PET/CT imaging were measured and the change of SUVmax (△SUVmax) was calculated. The sensitivity, specificity and accuracy were calculated using the △SUVmax≥0 as diagnostic positive standard, and the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic vale of △SUVmax for low metabolic SPN. Results: The differences in average SUVmax of early and delayed imaging between benign and malignant nodules had no statisticly significance (t=0.193, P=0.848, t=1.452, P=0.154). There was significant difference in mean △SUVmax between malignant and benign lesions (t=2.738, P=0.009). The sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 87.88%, 66.67%, 82.22%, 87.88% and 66.67% respectively with △SUVmax≥0 as diagnostic positive standard. The area under ROC curve was 0.861 according to the △SUVmax. Conclusion: The dual time point PET/CT imaging is useful for differentiating solitary pulmonary nodules with early SUVmax≤2.5 and without specific morphological characteristics.
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Received: 21 August 2013
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WU Ganggang, BIAN Xuefei, ZHOU Qi, ZHANG Xiaote, ZHU Yun, TAO Zeru, SHAO Shengyan, FENG Shanshan, WANG Hongli, YANG Youxiong. Analysis of related factors in clinical staging of nasopharyngeal carcinoma patients[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(7): 577-581. |
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2014, Vol. 44 
