Tourette综合征患儿症状严重程度与静息态功能磁共振脑低频振幅的关系

doi:10.3969/j.issn.2095-9400.2020.05.013

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Abstract Objective: To analyze the relationship between the amplitude of low-frequency fluctuation (ALFF) of resting functional magnetic resonance imaging under resting state and the severity degree of Tourette syndrome in children. Methods: 20 first-episode children with Tourette syndrome, admitted by the First People’s Hospital of Taizhou from February 2017 to April 2018, were recruited in the study, and all the patients were examined by fMRI. The ALFF of brain was respectively calculated in different frequency bands, and the relationship between the severity of symptoms and the ALFF was discussed that. Results: It was shown that a positive correlation between the score of symptom severity in orbital part of left superior forehead gyrus, right-to-middle frontalis orbital, left middle frontalis orbital region and the ALFF (P<0.05), and a negative correlation between the score of symptom severity in left distal sulcus, right distal sulcus, peripheral cortex and the ALFF (P<0.05). Conclusion: There is a significant correlation between the severity of symptoms in children with Tourette syndrome in resting state and abnormal brain function at regions.

Key words： Tourette syndrome resting state functional magnetic resonance imaging amplitude of lowfrequency fluctuation

Received: 01 December 2019

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	ZHAO Wuhua
	XIA Xianwu
	FAN Qiwei
	ZHENG Hailan
	WANG lubing

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https://xb.wmu.edu.cn/EN/ 10.3969/j.issn.2095-9400.2020.05.013 OR https://xb.wmu.edu.cn/EN/Y2020/V50/I5/415

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