高龄女性血尿酸水平与肾功能的关联性

doi:10.3969/j.issn.2095-9400.2020.05.010

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Abstract Objective: To investigate the relationship between the renal function and the serum uric acid (SUA) level in elderly women. Methods: A total of 230 qualified female patients (71-93 years) were asked to complete a questionnaire and do medical checkups. Multiple linear regression and logistic regression were used respectively to analyze the association between SUA and renal function. Results: The prevalences of chronic kidney disease (CKD) in four SUA quartiles (UA1: 157-mmol/L, UA2: 262-μmol/L, UA3: 312-μmol/L, UA4: 362-556 μmol/L) were 31.58%, 39.66%, 53.45% and 84.21%, respectively, with significant difference (P<0.05). A significant inverse correlation was observed between the estimated glomerular filtration rate (eGFR) and SUA based on a multivariable linear regression model after adjusting age, body mass index (BMI) and total cholesterol (TC). Compared with those in UA1, higher SUA levels were significantly associated with a greater decline in eGFR (UA2: β=-4.50, 95%CI: -9.04, -0.04; UA3: β=-6.57, 95%CI: -10.67, -2.47; UA4: β=-13.48, 95%CI: -17.73, -9.23) after adjusting the above confounding factors. Meanwhile, a multiple logistic regression analysis clearly revealed that participants in the UA4 category had the highest odds to develop CKD as compared to their counterparts, in which the adjusted odds was 10.64 times of that in participants from UA1 (OR: 10.64, 95%CI: 4.15-27.34, P<0.01). Conclusion: Elevated SUA was an independent risk factor of the declined renal function and significantly associated with increased odds of CKD in old women.

Key words： old women serum uric acid renal function estimated glomerular filtration rate

Received: 28 May 2019

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	LAI Xiuxiu
	LAI Qinmei
	ZHOU Gongmin
	FENG Li
	YANG Ling.

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https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2020.05.010 OR https://xb.wmu.edu.cn/EN/Y2020/V50/I5/401

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