LINC00460在肾透明细胞癌中的表达及其临床意义

doi:10.3969/j.issn.2095-9400.2020.05.009

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Abstract Objective: To explore the expression and clinical significance of LINC00460 in clear cell renal cell carcinoma (ccRCC). Methods: Gene expression profiles of 611 ccRCC patients and their clinical data were downloaded from TCGA database. We studied the expression of LINC00460 in pairs of ccRCC tissues and matched non-cancerous adjacent tissues, and then analyzed the relationship between expression of LINC00460 and clinical parameters and prognosis of patients. Results: Over-expression of LINC00460 was found more in ccRCC tissues than non-cancerous adjacent tissues (P<0.05). The increased expression of LINC00460 was significantly associated with high pathological stage (I/II vs. III/IV, OR=2.82, 95%CI=1.96-4.07, P<0.001), T stage (T1/2 vs. T3/4, OR=2.65, 95%CI=1.84-3.84, P<0.001), N stage (N0 vs. N1, OR=7.80, 95%CI=2.12-50.40, P=0.007), M stage (M0 vs. M1, OR=3.22, 95%CI=1.91-5.61, P<0.001) and histological grade (G1/2 vs. G3/4, OR=2.08, 95%CI=1.46-2.95, P<0.001). Cox regression analysis showed that LINC00460 was an independent factor in predicting the overall survival of ccRCC patients (HR=1.05, 95%CI=1.01-1.10, P=0.010). Conclusion: LINC00460 have over-expression in ccRCC tissues than non-cancerous adjacent tissues. Patients of high LINC00460 expression have worse prognosis than patients of low LINC00460. Therefore, LINC00460 could be a biomarker for the prognosis of ccRCC patients.

Key words： clear cell renal cell carcinoma LINC00460 TCGA database

Received: 23 July 2019

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	WANG Chenfei
	LIU Bo
	ZHANG Changhuan
	WANG Jianying
	SU Ming

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https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2020.05.009 OR https://xb.wmu.edu.cn/EN/Y2020/V50/I5/395

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