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| A compositional analysis of adult nasal septal cartilage |
| XU Haiting1, HU Kepeng2, XUE Jixin1, SHI Li1, SONG Yonghuan1, LI Xiaoyang1 |
| 1.Department of Plastic Surgery, the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China; 2.Renji College, Wenzhou Medical University, Wenzhou 325035, China |
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| Cite this article: |
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XU Haiting,HU Kepeng,XUE Jixin, et al. A compositional analysis of adult nasal septal cartilage[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2020, 50(4): 328-330,333.
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Abstract Objective: To localize quantitatively the major biochemical constituents of human adult nasal septal cartilage, which may provide an experimental basis and theoretical guidance for clinical nasal septal cartilage transplantation. Methods: Seven adult corpse nasal septal cartilage specimens were obtained, each divided into 5 regions, labeled as A, B, C, D, and E respectively. Biochemical analysis was used to determine the relative wet weight of the main components of the septal cartilage: chondrocytes, collagen and sulfated glycosaminoglycans (sGAG). Results: Each milligram of wet cartilage fragment contains an average of (22 900±2 900) cells, (60.3±6.4) μg of collagen, and the average content of sulfated glycosaminoglycans (sGAG) was (14.6±3.5) μg per mg of wet weight. The number of cells and collagen did not change significantly in each region. Compared with region A and region C, the sGAG content in B and D regions was significantly increased (P<0.05). Compared with region A and region C, the ratio of collagen to sGAG in B, D and E regions was significantly decreased (P<0.05). Conclusion: The content of sGAG shows specific regional changes in the septal cartilage of the nasal septum. The local morphology of the sGAG deposition is consistent with the predominantly retained L-pillar shape in rhinoplasty or nasal reconstruction.
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