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| Interaction between BMI and lipid profile in diabetic kidney disease in Chinese Han population with type 2 diabetes |
| YU Weihui, HU Xiang, CHEN Xiong, ZHOU Qi, DENG Huihui, GU Xuejiang |
Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China
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| Cite this article: |
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YU Weihui,HU Xiang,CHEN Xiong, et al. Interaction between BMI and lipid profile in diabetic kidney disease in Chinese Han population with type 2 diabetes[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2020, 50(4): 290-294，299.
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Abstract Objective: To explore the interaction between BMI and lipid profile in diabetic kidney disease (DKD) in Chinese Han population with type 2 diabetes. Methods: We recruited 647 unrelated Han Chinese participants in this study, including 283 DKD patients and 364 non-DKD patients. Binary logistic regression was applied to analyze the association between lipid profile and DKD, and the interaction between BMI and lipid profile. Results: TG (OR=1.446, 95%CI: 1.076-1.942, P=0.014), nonHDL-C (OR=1.961, 95%CI: 1.011-3.804, P=0.046), nonHDL-C/HDL-C (OR=1.804, 95%CI: 1.134-2.869, P=0.013), TC/HDL-C (OR=2.293, 95%CI: 1.234-4.260, P=0.009), TG/HDL-C (OR=1.345, 95%CI: 1.057-1.712, P=0.016) were all significantly associated with DKD, ORs were calculated for the logarithmically transformed indexes. Significant interactions between BMI and TG, nonHDL-C/HDL-C, TC/HDL-C, TG/HDL-C were detected (P values equal to 0.036, 0.035, 0.034, 0.016, respectively). Conclusion: It is indicated that TG, nonHDL-C, nonHDL-C/HDL-C, TC/HDL-C, TG/HDL-C are significant risk factors for DKD in Chinese patients with type 2 diabetes. BMI modulated the association between lipid profile and DKD in this population.
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