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The value of forearm bone mineral density and bone metabolism index in the diagnosis of postmenopausal female rheumatoid arthritis complicated with osteoporosis |
XU Xiaozuo1, ZHU Xiaochun2 |
1.Department of Rheumatology and Immunology, Wenzhou Medical University Theorem Clinical College, Wenzhou Central Hospital, Wenzhou 325000, China; 2.Department of Rheumatology and Immunology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China |
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Cite this article: |
XU Xiaozuo,ZHU Xiaochun. The value of forearm bone mineral density and bone metabolism index in the diagnosis of postmenopausal female rheumatoid arthritis complicated with osteoporosis[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2020, 50(3): 241-244.
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Abstract Objective: To investigate the value of forearm bone mineral density (BMD) and bone metabolism markers in the diagnosis of postmenopausal female rheumatoid arthritis (RA) with osteoporosis (OP). Methods: Ninety six postmenopausal female rheumatoid arthritis (RA) and 25 postmenopausal healthy female were determined by DXA. Age, body mass index, erythrocyte sedimentation, C reaction protein, rheumatoid factor, type I collagen N-terminal peptide (PINP) and serum type I collagen crosslinked C-terminal peptide (β-CTX) horizontal bone metabolism index were collected.The correlation between bone density and experimental index was analyzed. Results: Bone density and bone mineral content in RA group were significantly lower than those in the control group, P<0.01). Statistical differences were found between RA and control group in bone metabolism index PINP [(79.01±44.72)μg/L vs. (96.74±50.92)μg/L, P=0.036] and β-CTX [(0.51±0.35)μg/L vs. (0.37±0.26)μg/L, P=0.009]; Linear correlation analysis showed that β-CTX was negatively related to BMD and BMC (r=-0.259, P=0.011; r=-0.300, P=0.003) in RA; Age is negatively related to BMD and BMC (r=-0.706, P<0.001; r=-0.743, P<0.001); DAS28 is negatively related to BMD and BMC (r=-0.400, P<0.001; r=-0.330, P=0.001); PINP is positively correlated with BMD and BMC (r=0.308, P=0.020; r=0.244, P=0.010); The logistic regression analysis showed that only age, β-CTX were the risk factors for osteoporosis (OR=0.450, 95%CI=0.606-0.921, P=0.006; OR=1.008, 95%CI=1.002-1.016, P=0.031); PINP is a protective factor for osteoporosis (OR=1.060, 95%CI=1.005-1.118, P=0.003). Conclusion: Postmenopausal female RA patients are more prone to osteoporosis than normal postmenopausal female, and bone metabolism index β-CTX may be an independent risk factor for postmenopausal female RA osteoporosis.
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