曲美他嗪对肾功能不全患者对比剂肾病的预防作用

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Abstract Objective: To evaluate the efficacy of trimetazidine (TMZ) in the prevention of contrast-induced nephropathy (CIN) in patients with renal insufficiency. Methods: We conducted a prospective, randomized, controlled trial, 124 patients undergoing coronary angiography/angioplasty were involved, whose stable serum creatinine levels were at least 103 μoml/L. They were divided into TMZ group (n=64) and control group (n=60) randomly, TMZ group received TMZ (20 mg thrice daily) orally for 7 d starting 48 h before the procedure. All patients were given routine hydration treatment before and after the procedure. Serum creatinine (Scr) levels were measured before the procedure, 24 h, 48 h and 7 d after the procedure. Results: ①Scr levels had no statistical significance in the two groups 24 h after the procedure (P>0.05). ②Scr levels significantly decreased after 48 h and 7 d in the TMZ group (P<0.05). ③CIN developed in 3.1% of patients in the TMZ group and in 16.7% of patients in the control group (P<0.05). Conclusion: TMZ along with isotonic saline hydration is more effective than isotonic saline alone in reducing the risk of CIN in patients with renal insufficiency

Key words： trimetazidine contrast-induced nephropathy prevention

Received: 22 July 2013

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	CHEN Yan
	HU Yadi
	YE Xiaorong.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2014/V44/I9/675

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