SLC1A1基因多态性与中国汉族人群强迫症的相关性

doi:10.3969/j.issn.2095-9400.2020.03.014

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1458 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To investigate the relationship between solute carrier family 1 member 1 gene (SLC1A1) and obsessive-compulsive disorder (OCD) in Chinese Han population. Methods: A case-control study was conducted on 125 patients (OCD group) and 125 normal people (control group) to detect 3 loci of SLC1A1 gene (rs301430, rs301434, rs301979). The allele and genotype distribution of these loci and the relationship between haploid and OCD were analyzed. Results: There was no significant difference in allele and genotype frequency distribution of 3 loci between OCD group and control group (P>0.05). Gender stratified analysis showed that the frequency distribution of allele and genotype of rs301979 site in female patients was significantly different from that in the control group (χ2=7.875, P=0.019; χ2=7.331, P=0.007), while the distribution of allele and genotype frequency of all loci in male patients was not statistically significant (P>0.05). The difference between haploid T-A-G of 3-loci in the 2 groups was statistically significant (χ2=6.206, P=0.013). Conclusion: The rs301979 site of SLC1A1 gene may be the susceptibility gene site of female OCD, and the haploid T-A-G of rs301430, rs301434 and rs301979 may be related to the incidence of OCD in Chinese Han population.

Key words： obsessive-compulsive disorder solute carrier family 1 member 1 polymorphism susceptibility gene

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	REN Jianjuan
	TANG Mouni
	CHEN Xiaoying
	FU Zhengchuang

URL:

https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2020.03.014 OR https://xb.wmu.edu.cn/EN/Y2020/V50/I3/237

[1] NAAIJEN J, LYTHGOE D J, AMIRI H, et al. Fronto-striatal glutamatergic compounds in compulsive and impulsive syndromes: a review of magnetic resonance spectroscopy stud-ies[J]. Neurosci Biobehav Rev, 2015, 52: 74-88.
[2] CHAKRABARTY K, BHATTACHARYYA S, CHRISTOPHER R, et al. Glutamatergic dysfunction in OCD[J]. Neuropsychopharmacology, 2005, 30(9): 1735-1740.
[3] CORIC V, TASKIRAN S, PITTENGER C, et al. Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial[J]. Biol Psychiatry, 2005, 58(5): 424-428.
[4] GRANT P, LOUGEE L, HIRSCHTRITT M, et al. An open-label trial of riluzole, a glutamate antagonist, in children with treatment-resistant obsessive-compulsive disorder[J]. J Child Adolesc Psychopharmacol, 2007, 17(6): 761-767.
[5] BERGLES D E, JAHR C E. Synaptic activation of glutamate transporters in hippocampal astrocytes[J]. Neuron, 1997, 19(6): 1297-1308.
[6] BERGLES D E, JAHR C E. Transporters buffer synaptically released glutamate on a submillisecond time scale[J]. J Neurosci, 1997, 17(12): 4672-4687.
[7] Walitza S, Wendland J R, Gruenblatt E, et al. Genetics of early-onset obsessive-compulsive disorder[J].Eur Child Adolesc Psychiatry, 2010, 19(3): 227-235.
[8] ARNOLD P D, SICARD T, BURROUGHS E, et al. Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder[J]. Arch Gen Psychiatry, 2006, 63(7): 769-776.
[9] DICKEL D E, VEENSTRA-VANDERWEELE J, COX N J,
et al. Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder[J]. Arch Gen Psychiatry, 2006, 63(7): 778-785.
[10] SHUGART Y Y, WANG Y, SAMUELS J F, et al. A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder in 378 families[J]. Am J Med Genet B Neuropsychiatr Genet, 2009, 150B(6): 886-892.
[11] SAMUELS J, WANG Y, RIDDLE M A, et al. Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder[J]. Am J Med Genet B Neuropsychiatr Genet, 2011,156B(4): 472-477.
[12] STEWART S E, FAGERNESS J A, PLATKO J, et al. Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder[J]. Am J Med Genet B Neuropsychiatr Genet, 2007, 144B(8): 1027-1033.
[13] Wu H S, Wang X M, Xiao Z P, et al. Association between SLC1A1 gene and early-onset ocd in the han chinese population: A case-control study[J]. J Mol Neurosci, 2013, 50(2): 353-359.
[14] STEWART S E, MAYERFELD C, ARNOLD P D, et al. Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1[J]. Am J Med Genet B Neuropsychiatr Genet, 2013, 162B(4): 367-379.
[15] Shi Y Y, He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci[J]. Cell Res, 2005, 15(2): 97-98.
[16] HETTEMA J M, NEALE M C, KENDLER K S, et al. A review and meta-analysis of the genetic epidemiology of anxiety disorders[J]. Am J Psychiatry, 2001, 158(10): 1568-1578.
[17] VEENSTRA-VANDER WEELE J, KIM S J, GONEN D,
et al. Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder[J]. Mol Psychiatry, 2001, 6(2): 160-167.
[18] HANNA G L, VEENSTRA-VANDER WEELE J, COX N J, et al. Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric pro-bands[J]. Am J Med Genet, 2002, 114(5): 541-552.
[19] KIM H W, KANG J I, HWANG E H, et al. Association between glutamate transporter gene polymorphisms and obsessive-compulsive disorder/trait empathy in a Korean popula-tion[J]. PLoS one, 2018, 13(1): e0190593.
[20] ZHANG K, CAO L, ZHU W, et al. Association between the efficacy of fluoxetine treatment in obsessive-compulsive disorder patients and SLC1A1 in a Han Chinese population[J]. Psychiatry Res, 2015, 229(1-2): 631-632.
[21] 丛金芝, 张心华. SLC1A1基因rs3087879位点多态性与强迫症的关系[J]. 青岛大学医学院学报, 2016, 3(52): 345-347, 351.