成人重症腺病毒肺炎临床特征及预后

doi:10.3969/j.issn.2095-9400.2020.03.013

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Abstract Objective: To investigate the clinical features and prognosis of adult severe adenovirus pneumonia. Methods: Adult cases with severe adenovirus pneumonia who were admitted in the First Affiliated Hospital of Wenzhou Medical University from March 2017 to May 2019 were retrospectively analyzed. Results: Seven male patients aged 23-50 years, with an average age of (35±10) years, were enrolled. The main clinical symptoms were fever (7/7 cases), dyspnea (7/7 cases), cough (7/7 cases) and chest pain (1/7 cases). APACHE II score was 5-20 points, with an average points (10.1± 5.0). Laboratory test included normal BRT value and increased creatine kinase. Adenovirus was identified by metagenomics next-generation sequencing (mNGS) in 6 cases, and 1 case was confirmed through positive adenovirus antigen from BALF. There were 3 cases of serotype 7, 2 cases of type 55, 1 case of type 4, and 1 case unknown. Three patients were supported by tracheal intubation ventilator, 1 patient underwent tracheotomy and ventilator support and 3 patients were supported by noninvasive ventilator, with the mechanical ventilation time lasting from 5 to 46 days. Once the adenovirus was diagnosed, all patients were treated with intravenous gamma globulin, three of whom were treated with intravenous ganciclovir and ribavirin. Six cases were discharged and one patient died. Conclusion: Adult severe adenovirus pneumonia occurs most common in young and middle-aged males. mNGS can identify the pathogen rapidly. Active and effective treatment is necessary.

Key words： adenovirus severe community-acquired pneumonia adult

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	ZHANG Shengnan
	ZHOU Ying
	YE Junru
	ZHANG Dongqing
	ZHOU Lingping
	LI Yuping

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https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2020.03.013 OR https://xb.wmu.edu.cn/EN/Y2020/V50/I3/232

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