新型冠状病毒S蛋白B细胞表位的预测与分析

doi:10.3969/j.issn.2095-9400.2020.03.001

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Abstract Objective: To predict the secondary structure and B-cell epitopes of S protein of SARS-CoV-2. Methods: The amino acids of SARS-CoV-2 S protein were selected, and the secondary structure was predicted by SOPMA and GOR methods. A combined comprehensive analysis of transmembrane domain, hydrophilicity profile, surface probability and antigenicity index was further made to predict B-cell epitopes of S protein. Results: Prediction of the secondary structure of SARS-CoV-2 S protein indicated that random coils were the main structural type of the flexible region in secondary structure. The predominant B-cell epitopes were probably in the regions of 354-360, 437-445, 454-471, 527-537, 567-582, 678-685, 772-779 and 806-818 amino acids. Conclusion: The B-cell epitope of SARS-CoV-2 S protein can be predicted by multi parameters, which lays foundations for further study of the function of S protein.

Key words： SARS-CoV-2 S protein B-cell epitope prediction

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	ZHU Shanli
	DING Ning
	XIANG Dan
	DONG Haiyan
	XUE Xiangyang
	ZHANG Lifang

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https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2020.03.001 OR https://xb.wmu.edu.cn/EN/Y2020/V50/I3/173

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