急性心肌梗死患者cd42b、cd62p、Hcy及hs-CRP与冠状动脉病变程度的相关性

doi:10.3969/j.issn.2095-9400.2019.12.016

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1505 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To investigate the correlation between cd42b, cd62p, homocysteine (Hcy) and high-sensitivity C-reactive protein (hs-CRP) and severity of coronary artery disease in patients with acute myocardial infarction (AMI). Methods: Totally 154 patients with AMI were enrolled. According to the Gensini score, they were divided as L group (≤55 points), M group (56-84 points) and H group (85-172 points). The differences in levels of cd42b, cd62p, Hcy and hs-CRP were compared between the three groups. The differences in cd42b, cd62p, Hcy and hs-CRP levels were compared between patients with different coronary lesions. The correlation between cd42b, cd62p, Hcy and hs-CRP and the extent of coronary lesions was analyzed. Results: The levels of cd62p, Hcy and hs-CRP were significantly different between groups (P<0.05). The cd62p, Hcy and hs-CRP levels in group M were significantly higher than those in group L (P<0.05). The levels of cd62p, Hcy, hs-CRP and hs-CRP were significantly higher in group H than those of L and M groups (P<0.05). There was no significant difference in cd42b levels between groups. The levels of cd62p, Hcy and hs-CRP in different lesions were significantly different (P<0.05). The levels of cd62p, Hcy and hs-CRP in patients with 2 and 3 lesions were significantly higher than those with 1 lesion (P<0.05). The levels of cd62p, Hcy and hs-CRP in patients with 3 lesions were significantly higher than those with 2 lesions (P<0.05). With the increase of Gensini score, cd42b showed a downward trend, with group L the highest level of cd42b, and group H the lowest level of cd42b. There was a significant positive correlation between cd62p, Hcy and hs-CRP and Gensini score (P<0.05). Conclusion: cd62p, Hcy and hs-CRP are significantly positively correlated with the degree of coronary artery lesions in patients with AMI, suggesting the detection of cd62p, Hcy and hs-CRP levels could be used to understand the degree of coronary artery lesions in AMI patients.

Key words： acute myocardial infarction cd42b cd62p homocysteine hypersensitive C-reactive protein coronary artery disease

Received: 19 April 2019

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	FENG Yan
	LI Yanmin
	CHAI Liangting
	LI Jing
	ZHANG Yan

URL:

https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2019.12.016 OR https://xb.wmu.edu.cn/EN/Y2019/V49/I12/930

[1] JAING T H, CHEN S H, WEN Y C, et al. Assessment of platelet activation and immature platelet fraction as predictors of platelet engraftment after hematopoietic stem cell transplantation[J]. Cell Transplant, 2016, 25(7): 1259-1264.
[2] FU Z, YANG X, SHEN M, et al. Prognostic ability of cystatin C and homocysteine plasma levels for long-term outcomes in very old acute myocardial infarction patients[J]. Clin Interv Aging, 2018, 13: 1201-1209.
[3] WALDEYER C, BRUNNER F J, BRAETZ J, et al. Adherence to Mediterranean diet, high-sensitive C-reactive protein, and severity of coronary artery disease: Contemporary data from the INTERCATH cohort[J]. Atherosclerosis, 2018, 275: 256-261.
[4] 中华医学会心血管病学分会, 中华心血管病杂志编辑委员会, 中国循环杂志编辑委员会. 急性心肌梗死诊断和治疗指南[J]. 中华心血管病杂志, 2001, 29(12): 705-720.
[5] JONGEN M, ENGLYST N, WEST J. Investigating platelet functional heterogeneity using droplet microfluidics[J]. Heart, 2016, 102(6): A129-A130.
[6] HARTOPO A B, PUSPITAWATI I, GHARINI P P, et al. Platelet microparticle number is associated with the extent of myocardial damage in acute myocardial infarction[J]. Arch Med Sci, 2016, 12(3): 529-537.
[7] FRÖHLICH M, SCHÄFER N, CASPERS M, et al. Temporal phenotyping of circulating microparticles after trauma: A prospective cohort study[J]. Scand J Trauma Resusc Emerg Med, 2018, 26(1): 33-35.
[8] 吴方辉, 刘金来, 张江武, 等. 缺血后适应改善急性心肌梗死PCI术中血小板功能与临床预后的关系[J]. 实用医学杂志, 2018, 34(11): 1872-1875.
[9] CHIVA-BLANCH G, LAAKE K, MYHRE P, et al. Platelet-, monocyte-derived and tissue factor-carrying circulating microparticles are related to acute myocardial infarction severity[J]. PLoS One, 2017, 12(2): e0172558.
[10] 李霞, 郭殿选, 李侠. 不同程度老年慢性左心衰竭患者CD42b、hs-CRP和CD61的表达[J]. 现代中西医结合杂志, 2013, 22(25): 2737-2738.
[11] 权晓慧, 张春艳, 王聪霞, 等. CD31+/CD42b-、CD144+内皮微粒水平与颈动脉内膜中层厚度的关系[J]. 西安交通大学学报(医学版), 2016, 37(3): 327-330.
[12] 张秋焕, 辛成德, 钟白云. 同型半胱氨酸和超敏C反应蛋白与冠状动脉粥样硬化性心脏病的相关性分析[J]. 中国现代医学杂志, 2017, 27(28): 66-69.
[13] MA Y, PENG D, LIU C, et al. Serum high concentrations of homocysteine and low levels of folic acid and vitamin B12, are significantly correlated with the categories of coronary artery diseases[J]. BMC Cardiovasc Disord, 2017, 17(1): 37-39.
[14] DHAR I, GFT S, PEDERSEN E R, et al. Plasma cystathionine and risk of acute myocardial infarction among patients with coronary heart disease: Results from two independent cohorts[J]. Int J Cardiol, 2018, 266: 24-30.
[15] 周志兰, 刘超英, 李晓辕, 等. 血浆Hcy水平与冠状动脉病变程度的相关性[J]. 中国老年学杂志, 2013, 33(3): 659-660.
[16] ZHANG J, ZHANG X, CUI Y, et al. Different postconditioning cycles affect prognosis of aged patients undergoing primary percutaneous coronary intervention[J]. Cardiol J, 2017, 25(6): 666-673.
[17] POKHAREL Y, SHARMA P P, QINTAR M, et al. High-sensitivity C-reactive protein levels and health status outcomes after myocardial infarction[J]. Atherosclerosis, 2017, 266(11): 16-23.
[18] RAZBAN M M, ESLAMI M, BAGHERZADEH A. The relationship between serum levels of hs-CRP and coronary lesion severity[J]. Clujul Med, 2016, 89(3): 352-364.