住院患者使用利奈唑胺致贫血的相关危险因素

doi:10.3969/j.issn.2095-9400.2019.12.009

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Abstract Objective: To investigate the factors affecting linezolid-induced anemia in hospitalized patients.Methods: A retrospective study was performed to collect data in 161 adult inpatients who received linezolid between May 2012 to May 2017. The risk factors of linezolid-related anemia were confirmed by univariate and multivariate logistic regression. Results: Of all the patients enrolled, linezolid-induced anemia developed in 31 (19.2%) patients during therapy. The incidence of anemia occurred more frequently in patients who received linezolid at concentration≥7 mg·L-1 (OR=2.87, 95%CI: 1.11-6.93, P=0.024) and those with moderate-severe renal impairment [GFR<60 mL·(min·1.73 m2)-1] (OR=3.47, 95%CI: 1.49-8.13, P=0.004). Conclusion: The results of our study indicated that high plasma linezolid concentration and renal impairment significantly affected the development of linezolid-induced anemia.

Key words： linezolid anemia plasma concentration renal insufficiency risk factor

Received: 06 September 2019

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	DAI Ying
	JIANG Shuying
	YU Xuben
	ZHANG Chunhong
	HU Lufeng
	LIN Guanyang

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https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2019.12.009 OR https://xb.wmu.edu.cn/EN/Y2019/V49/I12/900

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