RETN、LEPR和ADIPOQ基因多态性与中国汉族人群2型糖尿病风险及血脂代谢的关系

doi:10.3969/j.issn.2095-9400.2019.11.005

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Abstract Objective: To investigate the association of resistin gene (RETN), leptin receptor gene (LEPR) and adiponectin gene (ADIPOQ) polymorphisms encoding adipokines with the risk of type 2 diabetes mellitus (T2DM) and the effect on lipid metabolism in Chinese Han population. Methods: A total of 526 T2DM patients and 344 nondiabetic controls were enrolled in our study. The single-nucleotide polymorphisms (SNPs) of RETN (rs1862513, rs3745367), LEPR (rs1137101, rs13306519, rs1805096) and ADIPOQ (rs1501299, rs2241766) were determined by the kompetitive allele specific PCR (KASP) technique. The association of RETN, LEPR and ADIPOQ polymorphisms with the risk of T2DM and the relationship between various SNP genotypes and lipid metabolism were applied by statistical methods. Results: The frequency of GG genotype and G variant allele of RETN rs1862513 in the T2DM group was higher than the control group, and the difference was statistically significant (42.0% vs. 30.0%, P=0.003; 65.0% vs. 57.1%, P=0.001, OR=1.397, 95%CI=1.140-1.712); Further analysis of the overall study population found that the frequency of RETN rs1862513 GG genotype in the T2DM group was visibly higher than the control group in the BMI<25 kg/m2 group after grouped by BMI (42.8% vs. 31.0%, P=0.015). Further analysis of the relationship between each genotype and lipid, RETN rs3745367 GG or AG genotype had lower high density lipoprotein cholesterol (HDL) level at BMI<25 kg/m2 (P=0.018); LEPR rs13306519 CC or CG genotype had lower HDL level at BMI≥25 kg/m2 (P=0.016). In the overall study population, ADIPOQ rs1501299 CC or AC genotype had higher triglyceride (TG) level than AA genotypes (P=0.044). Conclusion: RETN rs1862513 G allele may be associated with the risk of T2DM in Chinese Han population; ADIPOQ rs1501299 CC or AC genotype may be associated with high TG level, RETN rs3745367 GG or AG genotype in non-obesity and LEPR rs13306519 CC or CG genotype in obese people may be associated with low HDL level.

Key words： resistin leptin receptor adiponectin type 2 diabetes mellitus gene polymorphism lipid metabolism

Received: 14 October 2018

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	ZHENG Wenwen
	ZHANG Hang
	ZHOU Xinhe
	HONG Ying
	ZHUANG Fei
	WU Chenwei
	CHEN Xia
	HE Hanghui
	SU Yue
	ZHENG Chao

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https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2019.11.005 OR https://xb.wmu.edu.cn/EN/Y2019/V49/I11/807

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