亮氨酸对大鼠肝部分切除术后肝再生的影响

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Abstract Objective: To investigate the effect of amino acid solutions with different leucine concentrations on liver regeneration after partial hepatectomy in rats. Methods: After 70% hepatectomy, eighteen SD rats were fed via gastric tube with one of the following amino acid solutions (1 g/kg): balanced amino acid (BAA group), branched chain amino acid (BCAA group) and leucine (Leu group). They were different in leucine concentrations. Liver regeneration was determined by residual liver/body weight ratio, ki-67 and PCNA positive counts 7 days later. Results: Compared with BAA group, the residual liver/body weight ratio, ki-67 and PCNA positive counts in Leu group were significantly increased (P<0.05), and were higher than those in BCAA group. Ki-67 and PCNA positive counts in BCAA group were significantly increased too when compared to BAA group, but residual liver/body weight ratio showed no significant difference between the two groups. Conclusion: Leucine can promote liver regeneration after partial hepatectomy in rats, and is more effective than branched chain amino acid.

Key words： leucine branched chain amino acid hepatectomy liver regeneration rats

Received: 25 February 2019

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	LIN Jianhua
	HONG Zhong
	ZHOU Bin

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2019/V49/I10/753

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