4种炎症因子在牙周炎与冠心病相关性中的作用

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Abstract Objective: To study the possible role of inflammatory factors (including IL-1β, IL-6, TNF-α, MCP-1) in the association between periodontal diseases and CHD. Methods: A total of 129 cases were selected from the Department of Stomatology of Wenzhou Chinese Medicine Hospital and the Cardiovascular Department of Wenzhou People’s Hospital from July 2015 to May 2016, including 39 healthy swarm (HC group), 35 cases of chronic moderate and severe forms of periodontitis (PD group), 31 cases of coronary heart disease alone (CHD group) and 24 cases of coronary artery disease along with periodontitis (PD+CHD group). The IL-1β, IL-6, TNF-α and MCP-1 in the serum of each recipient were detected by ELISA method. Results: There was statistical difference in IL-1β, IL-6, TNF-α, MCP-1 among enrolled groups (P<0.05) .The levels of IL-1β, IL-6, TNF-α and MCP-1 were highest in PD+CHD group, while the levels of IL-1β, IL-6 and TNF-α in PD group and CHD group were higher than those in HC group. Conclusion: The elevated serum levels of IL-1β, IL-6 and TNF-α in patients with moderate to severe periodontitis may promote the progression of CHD.

Key words： periodontitis coronary heart disease interleukin-1beta interleukin-6 tumor necrosis factor-alpha monocyte chemotactic protein 1

Received: 04 June 2018

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	MA Sihuan
	DENG Hui
	WANG Caiqiong

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2019/V49/I10/735

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