孕周相关外周血血小板参数参考区间调查

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Abstract Objective: To explore the variation of platelet count (PLT), immature platelet fraction (IPF), absolute value of immature fraction (IPF#), high-fluorescence intensity of immature platelet fraction (H-IPF), and mean side fluorescence intensity of platelet (PLT-X) in the pregnant women of different gestation, then to establish the reference intervals of these parameters. Methods: 1 272 normal pregnant women (20 to 30 years old) from October 2016 to October 2018 were selected, and they were divided into three groups: 348 cases of early trimester group (≤12 weeks), 369 cases of second trimester group (13 to 27 weeks) and 555 cases of third trimester group (≥28 weeks), second and third trimester group included 924 cases. Also, 200 cases of non-pregnant women of 20 to 30 years old were included as control group. At the same time, 88 cases of pregnant women with pre-eclampsia and 100 cases of gestational diabetes were collected. The PLT, IPF, IPF#, H-IPF and PLT-X of peripheral vein blood were determined by Sysmex XE-5000 and the reference intervals were established by using 95% confidence interval. Results: The PLT of the pregnant women was lower than the control group (P<0.05), but the parameters of IPF, IPF#, H-IPF and PLT-X were higher than the latter. The IPF, IPF#, H-IPF and PLT-X increased with the increase of gestational weeks in the early, second and third trimester groups (P<0.05). There was no statistically significant difference in PLT and H-IPF between early and second trimeter groups (P>0.05), but there were significant differences in PLT and H-IPF between early and second trimeter groups with third trimeter one (P<0.05). The PLTs of the pregnant women with pre-eclampsia and gestational diabetes were lower than the second and third trimester group, but the parameters of IPF, IPF#, H-IPF and PLT-X were higher than the latter. Conclusion: Platelet related parameters varied with the development of pregnant women during pregnancy, and the platelet parameters reference intervals during different trimeters of pregnancy were the basis for assessing the pathological state of pregnancy.

Key words： platelet immature platelet fraction reference interval pregnant women immature platelet fraction

Received: 05 March 2019

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	JIANG Weiyan
	LIN Xiang
	YU Lingling
	LI Mianmian
	MI Tian
	CHEN Xiaojian

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2019/V49/I9/677

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