不同浓度交泰丸及其组成药物对小鼠镇静作用的比较

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Abstract Objective: To compare sedative effects of Jiao-Tai-Wan with separated prescriptions of Coptis and Cinnamon on mice. Methods: Jiao-Tai-Wan groups were intragastric administrated 7 days by Jiao-Tai-Wan respectively with high, medium and low dosage of 0.220, 0.110 and 0.055 g/mL. Coptis groups were respectively administrated 7 days by Coptis with high, medium and low dosage of 0.200, 0.100 and 0.050 g/mL. Cinnamon high dose group was administrated 7 days by Cinnamon with concentration of 0.030 g/mL. Positive control group was administrated by Zolpidem with concentration of 0.200 g/mL. Blank control group was injected with water. The locomotor activity meter was used to determine the total number of locomotor activities of mice within 15 min, 30 min, 1 h, 3 h, 12 h, 24 h after administration from day 1 to day 7. The number of locomotor activities of mice on day 8 without administration continued to be monitored. Results: On day 1 within 30 min, 1 h, 3 h, 12 h, 24 h after administration, the number of locomotor activities of Jiao-Tai-Wan group with high dose was statistically declined respectively compared with blank control group (P<0.05). These differences were observed again on day 3, day 5, day 7. These differences remained on day 8 without administration. On day 3, day 5, day 7 within 1 h, the number of locomotor activities of Jiao-Tai-Wan group with medium dose were statistically declined respectively compared with blank control group (P<0.05). On day 7 within 1 h, the number of locomotor activities of Jiao-Tai-Wan group with low dose was statistically declined comparing with blank control group (P<0.05). On day 3, day 5, day 7 within 15 min and 1 h, the frequency of locomotor activity of Coptis groups with high dosage and medium dosage were statistically declined respectively compared with blank control group (P<0.05). On day 7 within 3 h, 12 h and 24 h after drug administration, the frequency of locomotor activity of Coptis group with high dosage was statistically declined c respectively omparing with blank control group (P<0.05). Conclusion: Jiao-Tai-Wan can produce a sedative effect, in which Coptis plays a major role.

Key words： Jiao-Tai-Wan sedation locomotor activity Coptis Cinnamon mice

Received: 06 July 2018

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	NI Xiaofen
	Lin Sisi
	CHEN Qian
	YUAN Zhengzhong

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2019/V49/I9/639

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