重度子痫前期并发急性左心衰相关指标的变化及诊断意义

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Abstract Objective: To analyze changes of related indicators in patients with severe preeclampsia (SPE) complicated with acute left heart failure. Methods: A total of 72 cases of SPE were selected as subjects. They were assigned into two groups: the observation group (22 cases) with acute left heart failure and the control group (50 cases) without acute left heart failure. Meaningful indicators were analyzed by logistic regression analysis. Meanwhile, ROC curve was drawn to evaluate their diagnostic value. Results: ①The findings showed that the heart rate, respiratory rate, BNP, NLR, CRP, creatinine and troponin I in the observation group were higher than those in the control group; The oxygen saturation and LVEF in the observation group were lower than those in the control group (P<0.05); ②Logistic regression analysis showed that elevated levels of BNP, NLR, CRP and troponin I were independent risk factors for SPE complicated with acute left heart failure; [OR(95%CI): 1.01(0.89-1.62), 1.61(0.97-2.68), 1.27(1.06-1.51) and 5.65(1.46-21.95), all P<0.05]. ③When levels of BNP (NLR) CRP and troponin I higher than the cut-off point, BNP in maternal blood was of the greatest value in the diagnosis of SPE complicated with acute left heart failure among all single markers, followed by NLR, CRP and troponin I in maternal blood (The AUC were 0.712, 0.683, 0.658 and 0.657, respectively). When four indexes (BNP, NLR, CRP and troponin I) were used in combination, AUC was 0.732. Conclusion: The elevated levels in maternal blood of BNP, NLR, CRP, troponin I were associated with SPE complicated with acute left heart failure. The diagnostic value of four indexes combined was superior to that of a single index.

Key words： severe preeclampsia acute left heart failure brain natriuretic peptide neutrophil-to-lymphocyte ratio left ventricular ejection fractions

Received: 03 July 2018

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	WU Liqun
	XU Qun
	YAO Rui
	GAO Jie
	CAI Pingsheng

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2019/V49/I7/533

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