血清淀粉样蛋白A在Vogt-小柳原田综合征早期临床诊断中的价值

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Abstract Objective: To investigate the clinical value of serum amyloid A(SAA), c-reactive protein (CRP) and white blood cell count (WBC) in early diagnosis of Vogt-Koyanagi-Harada syndrome. Methods: Ninety-two patients with Vogt-Koyanagi-Harada syndrome admitted to the Eye Hospital of Wenzhou Medical University from June 2016 to March 2018 were selected as the study subjects; 78 patients with dry eye disease were selected as the eye disease control group and 95 normal people with gender and age matching as the normal control group. SAA and CRP levels of the three groups were detected by colloidal gold immunochromatography and immunofluorescence dry quantitative method respectively; WBC was detected by Sysmex XT-1800i automatic blood analyzer. Variables were compared using Kruskal-wallis test and diagnostic value was measured by using ROC curve. Results: SAA, CRP and WBC levels were significantly increased in the Vogt-Koyanagi-Harada syndrome patients group compared with the dry eye group and the control group, respectively, with statistical difference (P<0.05). Compared with the control group, the differences were not statistically significant in the dry eye group (P>0.05). SAA had positive correlation with CRP and WBC in Vogt-Koyanagi-Harada syndrome patients (all P<0.05). The levels of SAA and WBC were significantly lower after treatment than before treatment (all P<0.05), the levels of CRP were not significantly different before and after the treatment (P>0.05). According to ROC curve analysis, the auC of SAA, CRP, WBC and combined detection for diagnosis of Vogt-Koyanagi-Harada syndrome were 0.905, 0.565, 0.888 and 0.952, respectively. The optimal cut-off values were 3.31 mg/L, 5.55 mg/L, and 8.175×109/L, respectively. The optimal cut-off value corresponding to the maximum value of Youden index was 0.667 by combined detection, with the sensitivity being 78.26% and the specificity 97.89%. Conclusion: SAA combined with CRP and WBC could improve the diagnostic efficacy of Vogt-Koyanagi-Harada syndrome. SAA can provide useful reference for the auxiliary diagnosis of Vogt-Koyanagi-Harada syndrome, which is worthy of wide clinical application.

Key words： Vogt-Koyanagi-Harada syndrome xerophthalmia serum amyloid A protein c-reactive protein white blood cell count

Received: 22 November 2018

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	YANG Yuanyuan
	LI Yali
	WANG Daxuan
	CHEN Pengfei
	ZHENG Meiqin

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2019/V49/I7/512

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