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| Grey matter volume changes in patients of mild traumatic brain injury: a voxel-based morphometry study |
| YANG Dengfa1, JIN Hanghuang2, ZHANG Sujuan1, YANG Ting1, WU Liang1, WANG Linyou1, SHEN Jianmin1, YU Xinfeng3 |
| 1.Department of Radiology, Taizhou Municipal Hospital, Taizhou 318000, China; 2.Department of Neurological Surgery, Taizhou Municipal Hospital, Taizhou 318000, China; 3.Department of Radiology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China |
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| Cite this article: |
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YANG Dengfa,JIN Hanghuang,ZHANG Sujuan, et al. Grey matter volume changes in patients of mild traumatic brain injury: a voxel-based morphometry study[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2019, 49(7): 497-500.
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Abstract Objective: To evaluate the volume changes of grey matter and its clinical significance in patients of mild traumatic brain injury with a voxel-based morphometry method. Methods: Whole brain structural images with FFE T1WI were acquired in 24 mTBI patients and 24 mTBI gender-and age-matched healthy controls, SPM8 was used to preprocess the collected data, and VBM software was used to analyze the whole brain structure. The difference of gray matter volume between the two groups was compared by double sample t test. Results: Decreased gray matter volumes were found in some regions including left cingulate gyrus, right cingulate gyrus, left shell nucleus, and right shell nucleusn (all P<0.05). Increased gray matter volumes were found in some regions including upper right frontal gyrus and middle left frontal gyrus. Clinical symptoms included neurologic symptoms, cognitive function and behavior disorders. There were headache and dizziness in 19 cases, memory decline in 12 cases, rage in 9 cases, inattention in 8 cases, unflexible body in 6 cases, two or more symptoms appeared in 15 cases at the same time. Conclusion: Changes of gray matter volume were demonstrated in mild traumatic brain injury patients with voxel-based morphometry method, which may be related to its clinical symptoms.
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Received: 25 September 2018
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