755 nm皮秒激光仪平光透镜与Focus蜂巢透镜联合应用治疗黄褐斑

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Abstract Objective: To observe the clinical efficacy and adverse effects of 755 nm picoseconds laser flat lens combined with focus lens array in the treatment of melasma. Methods: Totally 36 outpatients with melasma were treated with 755 nm picosecond laser flat lens combined with focus lens array for 6 treatment sessions at 4-week intervals. The patients were first treated with 755 nm picosecond laser flat lens. The treatment parameters: 0.4 J/cm2 of fluence, 8 mm of spot size and 5 Hz of frequency. Then they were treated with 755 nm picosecond laser focus lens array with the same parameters. Patients were all followed up for 12 weeks. Melasma area and severity index (MASI) scores were calculated after treatment, and related adverse reactions and patient satisfaction survey were recorded at the same time with statistical analysis followed. Results: The mean MASI scores before treatment, after 6 treatments and after 12-week follow up were (11.17±5.29), (4.63±3.05) and (5.11±3.23) respectively. The decreasing ration of the MASI score was (64±7)% after 6 treatments and (61±6)% after 12-week follow up. The mean MASI scores after 6 treatments and 12-week follow up were both lower than before treatment, and the difference was statistically significant (P<0.05). The mean MASI score after 12-week follow up was slightly higher than that after 6 treatments. The difference was not statistically significant (P>0.05). The decreasing ration of the MASI score in Fitzpatrick type III patients was (68±8)%, higher than that in Fitzpatrick type IV patients (56±6)%, and the difference was statistically significant (P<0.05). Patient satisfaction rate was 94.4% after 6 treatments and 88.9% after 12-week follow up respectively. Skintexture was finer and firmer, fine lines and coarse pores were obviously improved in most patients. No adverse reactions occurred in all patients. Conclusion: The combination ofpicosecond 755 nm laser flat lens with focus lens array is effective and safe with lower recurrence rate and higher patient satisfaction in the treatment of melasma and thus worthy of promotion.

Key words： 755 nm picosecond laser focus lens array melasma clinical efficacy

Received: 11 February 2019

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	PING Weidong
	ZHAO Qiming
	WANG Xin
	HUANG Xiaoxiang
	LI Fei
	WANG Yiran.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2019/V49/I6/442

[1] RODRIGUES M, PANDYA A G. Melasma: clinical diagnosis and management options [J]. Australas J Dermatol, 2015, 56(3): 151-163.
[2] LEE B W, SCHWARTZ R A, JANNIGER C K. Melasma [J]. G Ital Dermatol Venereol, 2017, 152(1): 36-45.
[3] 中国中西医联合学会皮肤性病专业委员会色素病学组, 中华医学会皮肤性病学分会白癜风研究中心, 中国医师协会皮肤科医师分会色素病工作组. 中国黄褐斑治疗专家共识（2015） [J]. 中华皮肤科杂志, 2016, 49(8): 529-532.
[4] TRIVEDI M K, YANG F C, CHO B K. A review of laser and light therapy in melasma [J]. Int J Womens Dermatol, 2017, 3(1): 11-20.
[5] GOKALP H, AKKAYA A D, ORAM Y. Long-term results in low-fluence 1064-nm Q-Switched Nd:YAG laser for melasma: Is it effective? [J]. J Cosmet Dermatol, 2016, 15(4): 420-426.
[6] TORBECK R, BANKOWSKI R, HENIZE S, et al. Lasers in tattoo and pigmentation control: role of the PicoSure(®) laser system [J]. Med Devices (Auckl), 2016, 9:63-67.
[7] CHESNUT C, DIEHL J, LASK G. Treatment of nevus of ota with a picosecond 755-nm alexandrite laser [J]. Dermatol Surg, 2015, 41(4): 508-510.
[8] YU W, ZHU J, YU W, et al. A split-face, single-blinded, randomized controlled comparison of alexandrite 755-nm picosecond laser versus alexandrite 755-nm nanosecond laser in the treatment of acquired bilateral nevus of Ota-like macules [J]. J Am Acad Dermatol, 2018, 79(3): 479-486.
[9] 朱丽萍, 庞勤, 吕乐春, 等. 黄褐斑患者组织病理特征分析 [J]. 中华皮肤科杂志, 2016, 49(10): 706-711.
[10] KWON S H, HWANG Y J, LEE S K, et al. Heterogeneous pathology of melasma and its clinical implications [J]. Int J Mol Sci, 2016, 17(6): 824.
[11] DIERICKX C. Using normal and high pulse coverage with picosecond laser treatment of wrinkles and acne scarring: Long term clinical observations [J]. Lasers Surg Med, 2018, 50(1): 51-55.
[12] CHAN J C, SHEK S Y, KONO T, et al. A retrospective analysis on the management of pigmented lesions using a picosecond 755-nm alexandrite laser in Asians [J]. Lasers Surg Med, 2016, 48(1): 23-29.
[13] ADATTO M A, AMIR R, BHAWALKAR J, et al. New and advanced picosecond lasers for tattoo removal [J]. Curr Probl Dermatol, 2017, 52:113-123.
[14] TANGHETTI E A. The histology of skin treated with a picosecond alexandrite laser and a fractional lens array [J]. Lasers Surg Med, 2016, 48(7): 646-652.
[15] WEISS R A, MCDANIEL D H, WEISS M A, et al. Safety and efficacy of a novel diffractive lens array using a picosecond 755 nm alexandrite laser for treatment of wrinkles [J]. Lasers Surg Med, 2017, 49(1): 40-44.
[16] LEE M C, LIN Y F, HU S, et al. A split-face study: comparison of picosecond alexandrite laser and Q-switched Nd:YAG laser in the treatment of melasma in Asians [J]. Lasers Med Sci, 2018, 33(8): 1733-1738.
[17] CHOI J E, LEE D W, SEO S H, et al. Low-fluence Q-switched Nd:YAG laser for the treatment of melasma in Asian patients [J]. J Cosmet Dermatol, 2018, 17(6): 1053-1058.
[18] HOFBAUER PARRA C A, CARETA M F, VALENTE N Y, et al. Clinical and Histopathologic assessment of facial melasma after low-fluence Q-switched neodymium-doped yttrium aluminium garnet laser [J]. Dermatol Surg, 2016, 42(4): 507-512.