血糖管理三人行项目中2型糖尿病患者的用药依从性

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Abstract Objective: To investigate and analyze the medication compliance of type 2 diabetes mellitus patients. Method: A total of 243 patients with type 2 diabetes in the First Affiliated Hospital of Wenzhou Medical University who participated in the “glucose optimization management project” (launched by the Chinese Medical Doctor Association and Sanofi) were divided into two groups depending on whether they had stopped taking drugs during the 12-week follow-up period. The general situation and clinical characteristics of the two groups before the use of basic insulin were compared and further analyzed by multiple logistic regression model. The differences between the two groups before the end of the 12-week follow-up period were observed. The causes of drug withdrawal and the distribution of time of drug withdrawal, the causes of drug withdrawal in different previous treatment schemes and the causes of drug withdrawal in different current treatment schemes were analyzed. Results: Compared with the group without discontinuation, the discontinuation group was found to have higher proportion of males, younger age, higher body mass index (BMI), shorter course of disease, lower initial fasting blood glucose and insulin dosage and fewer systemic complications (all P<0.05). In the discontinuation group, the number of discontinuation was the largest in the first week. The main reason for discontinuation was to change the treatment plan into oral hypoglycemic drugs only. Multivariate logistic regression analysis showed that shorter course of disease, higher initial fasting blood glucose, higher BMI and lower initial insulin dosage were the influencing factors of drug withdrawal (P<0.05), and shorter course of disease was the most important influencing factor (P<0.001). Conclusion: In the glucose optimization management project, poor compliance with medication occurred in patients with shorter course of disease, higher initial fasting blood glucose, higher BMI and lower initial insulin dosage. The main reason for discontinuation is to change the treatment plan into taking oral hypoglycemic drugs only.

Key words： diabetes mellitus, type 2 blood glucose management drug compliance

Received: 17 December 2018

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	SHEN Wen
	ZHOU Lingli
	JIANG Zipei

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2019/V49/I5/376

[1] NCD Risk Factor Collaboration. Worldwide trends in diabetes since 1980: apooled analysis of 751 population-based studies with 4.4 million participants[J]. The Lancet, 2016, 387(10027): 1513-1530.
[2] Huo X, Gao L, Guo L, et al. Risk of non-fatal cardiovascular diseases in early-onset versus late-onset type 2 diabetes in China: a cross-sectional study[J]. Lancet Diabetes Endo, 2016, 4(2): 115-124.
[3] Sosale A, Kumar K M P, Sadikot S M, et al. Chronic complications in newly diagnosed patients with type 2 diabetes mellitus in India[J]. Indian J Endocrinol Meta, 2014, 18(3): 355.
[4] Association, American Diabetes. 5. Prevention or delay of type 2 diabetes: standards of medical care in diabetes—2018 [J]. Diabetes Care, 41 (Suppl 1): S51.
[5] 郭晓蕙, 陈莉明, 陈丽, 等. 移动医疗患者管理模式对2型糖尿病基础胰岛素治疗依从性及血糖控制12周的效果评估[J]. 中华内分泌代谢杂志, 2016, 32(8): 639-644.
[6] CHAN J C N, GAGLIARDINO J J, BAIK S H, et al. Multifaceted determinants for achieving glycemic control: The International Diabetes Management Practice Study (IDMPS)[J]. Diabetes Care, 2009, 32(2): 227-233.
[7] 李忆琴, 吴礼凤, 余晓君, 等. 血糖管理三人行模式对2型糖尿病患者血糖控制的影响[J]. 实用糖尿病杂志, 2016, 11(6): 51-52.
[8] MARCOLINO M S, MAIA J X, ALKMIM M B, et a1. Telemedicine application in the care of diabetes patients: systematic review and meta-analysis[J]. PLoS One, 2013, 8(11): e79246.
[9] 中华医学会糖尿病分会. 成人2型糖尿病胰岛素临床应用的中国专家共识[J]. 中华内分泌代谢杂志, 2013, 29: 1-6.
[10] American Diabetes Association. Standards of medical care in Diabetes-2016[J]. Diabetes care, 2016, 39(suppl1): S1-Sl12.
[11] 洪益荣, 瞿佳, 黄芳. 多元化护理在2型糖尿病患者自我管理行为中的应用[J]. 温州医科大学学报, 2018, 48(2): 142-144.
[12] 中华医学会糖尿病分会. 中国2型糖尿病防治指南(2013年版)[J]. 中国医学前沿杂志(电子版), 2015, 7(3): 26-46.