琼脂糖/ε-PLL/CHA屏障膜的制备及其抑菌能力和生物性能评价

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Abstract Objective: To prepare a novel periodontal guided tissue regeneration (GTR) barrier membranes of agarose/ε-PLL/CHA and evaluation of it with excellent biocompatibility and antibacterial properties. Methods: CHA was prepared by the hydrothermal method. The characterization of the CHA were analyzed by Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The different concentrations of CHA and ε-PLL were added to the agarose to prepare the barrier membranes. The mechanical strength of barrier membranes was assessed through rheometer. Live/Dead staining was used to detect the biocompatibility of barrier membranes. The effect of antibacterial of barrier membranes was confirmed by inhibition zone. Results: SEM and FTIR indicated successful synthesis of hollow columnar CHA. Barrier membranes have good biocompatibility. CHA could enhance the mechanical properties of the barrier membranes. Live/Dead staining showed a good biocompatibility. There were obvious inhibition zones found around the barrier membranes. Conclusion: The agarose/ε-PLL/CHA barrier membrane was successfully prepared, and the membrane was proved to have good biocompatibility and antibacterial properties.

Key words： barrier membrane agarose poly-L-lysine carbonated hydroxyapatite antibacterial

Received: 17 December 2018

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	HE Zhiqi
	QIAN Qiuping
	DENG Hui
	HU Rongdang

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2019/V49/I4/267

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