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| Ultrasound and clinical assessment on the treatment of rheumatoid arthritis |
Department of Rheumatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015
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| Cite this article: |
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CHEN Dan,LI Yongji,WANG Xiaobing, et al. Ultrasound and clinical assessment on the treatment of rheumatoid arthritis[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(6): 431-434.
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Abstract Objective: To estimate the value of ultrasound (US) and clinical assessment on the treatment of rheumatoid arthritis (RA) patients in different stages. Method: Fourty-five RA patients, including early RA patients (group A) and non-early RA patients (group B) took traditional disease modifying anti-rheumatic drugs and etanercept for three months. Main evaluation indicators included the gray-scale US (GSUS) and the power Doppler US （PDUS） of the joints before treatment, during and after treatment, secondary evaluation indicators were clinical features, laboratory results, DAS28. Results: Compared to group B, the improvement of PDUS was greater in group A than group B after treatment for 6 weeks (2.07±0.41 vs 3.93±0.40, p<0.01) and 12 weeks (0.51±0.27 vs 1.47±0.26, p<0.05). The group A showed lower morning stiffness (0.00±0.04 vs 0.16±0.04, p<0.05), erythrocyte sedimentation rate (23.66±3.04 vs 36.84±2.97, p<0.01), c-reactive protein (6.29±1.79 vs 11.37±1.75, p<0.05), health assessment questionnaire (7.43±1.07 vs 12.73±0.97, p<0.01) than group B after treatment of 6 weeks, as well as the erythrocyte sedimentation rate (15.34±1.91 vs 23.11±1.87, p<0.01), health assessment questionnaire (2.71±0.98 vs 7.37±0.89, p<0.01) and disease activity score-28 (2.50±0.21 vs 3.20±0.20, p<0.05) after treatment of 12 weeks. And ultrasound alleviation was not showed in all clinical and laboratory remission. Conclusion: Ultrasound can accurately reflect the condition of RA involved joints, so it should be recommended in the follow-up of RA patients. Joint therapy with traditional DMARDs and etanercept helps for early and non-early RA patients, and the former is benefit more. Clinical and laboratory remission may not exclude joint inflammation in ultrasound.
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Received: 31 December 2013
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