男性2型糖尿病血尿酸水平与胰岛β细胞功能的相关性

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Abstract Objective: To investigate the correlation of serum uric acid and β-cell function in male type 2 diabetes. Methods: A total of 510 male patients who were clinically diagnosed as type 2 diabetes and received treatment at the First Affiliated Hospital of Nanjing Medical University between December 2014 and April 2016 were enrolled in this study. They were divided into hyperuricemia group (n=50) and normal uric acid group (n=460) based on the levels of serum uric acid. The body parameters, blood uric acid, biochemical indexes and islet autoantibodies were measured. The function of islet β-cell and insulin resistance was evaluated in parallel with mixed-meal tolerance test. Results: The linear correlation analysis between the two groups showed that the serum uric acid was positively correlated with ΔC30/ΔG30(r=0.122, P=0.006), iCpAUC180/iGAUC180 (r=0.304, P<0.001), HOMA2-% β(r=0.267, P<0.001), CpAUC180(r=0.328, P<0.001) and HOMA2-IR(r=0.248, P<0.001). The serum uric acid levels of the hyperuricemia and the normal uric acid groups were (480.63±57.39) and (304.22± 59.38) µmol/L respectively. Compared with the normal uric acid group, the hyperuricemia group showed significant higher HOMA2-IR (1.76±0.80 vs. 1.34±0.71, P<0.001), HOMA2-%β (89.15±47.64 vs. 67.18±30.88, P<0.001), ΔC30/ΔG30 (146.43±166.05 vs. 75.00±184.45, P=0.009), CpAUC180 (5 991.02±2 549.86 vs. 4 577.51±1 970.00,
P<0.001) and iCpAUC180/iGAUC180 (222.29±175.86 vs. 140.79±104.81, P<0.001). After adjusting the unbalanced factors between two groups, all calculated parameters of β-cell function and insulin resistance were also different between two groups. In the islet autoantibody negative patients, the hyperuricemia group had higher HOMA2-IR, HOMA2-%β, ΔC30/ΔG30, CpAUC180 and iCpAUC180/iGAUC180 (all P<0.05) compared to the normal uric acid group. After adjusting the unbalanced factors between two groups, HOMA2-%β, CpAUC180 and iCpAUC180/iGAUC180 were also significantly higher in the hyperuricemia group than those in the control group. But there were no statistical differences in HOMA2-IR (F=2.141, P=0.144) and ΔC30/ΔG30 (F=3.655, P=0.057) between two groups. Conclusion: The serum level of uric acid was positively correlated to islet β-cell function and insulin resistance evaluated in parallel with mixed-meal tolerance test. Metabolic syndrome and islet autoantibodies might affect the relationship between serum uric acid and islet β-cell function in male patients with type 2 diabetes.

Key words： serum uric acid diabetes mellitus, type 2 beta cell function islet autoantibodies

Received: 29 September 2018

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	HE Yinhui
	FU Qi
	YANG Tao

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2019/V49/I3/162

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