老年肌少症患者外周血白细胞及淋巴细胞亚群的分析

doi:10.3969/j.issn.2095-9400.2019.02.012

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Abstract Objective: To explore preliminarily the role of immune cells in pathogenesis of sarcopenia by detecting leukocyte, lymphocyte subsets and CRP of peripheral blood in patients with sarcopenia. Methods: A total of 120 old patients including 48 patients with sarcopenia and 72 patients without sarcopenia were selected in our study for the detection of leukocyte, lymphocyte subsets and CRP. Results: Leukocyte count of peripheral blood was (6.7±0.9)×109/L in sarcopenia group, and (5.5±0.8)×109/L in control group; NK cell was (30.4±6.6)% in sarcopenia group, and (25.4±7.2)% in control group; CRP was (6.3±1.2) mg/L in sarcopenia group, and (3.8±0.6) mg/L in control group. There were statistical differences between sarcopenia group and control group. However, the levels of total lymphocytes, CD4+T cells, CD8+T cells, B cells, NK like cells (CD3+CD56+), memory T cells (CD4+CD45RO+), naive T cells (CD4+CD45RA+), double negative T cells (CD3+CD4-CD8-) were not significantly different between sarcopenia group and control group. Conclusion: Leukocyte count, NK cells and CRP of sarcopenia patients are higher than the controls, which indicates micro-inflammatory and hypersensitivity of innate immunity in sarcopenia patients.

Key words： aged sarcopenia leukocyte lymphocyte subsets

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	Articles by authors
	WANG Yidong
	CHEN Yan
	WANG Shuangshuang
	DU Wenling
	ZHENG Yongke

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https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2019.02.012 OR https://xb.wmu.edu.cn/EN/Y2019/V49/I2/137

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