脐血Betatrophin水平与巨大儿发生的关系

doi:10.3969/j.issn.2095-9400.2019.02.008

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Abstract Objective: To investigate the 1evel of cord serum Betatrophin and its clinical significance in macrosomia. Methods: A cross-sectional study was conducted. Totally 30 macrosomias and 30 normal birth weight (NBW) infants were enrolled in the study. Puerpera and cord serum Betatrophin was determined.The correlation between cord serum Betatrophin and indexes of macrosomia development, lipid metabolic parameters and serum adiponectin were analyzed. Results: The serum Betatrophin in cord blood of macrosomia (1 088.338±67.749 ng/L) was significantly higher than that of in NBW (929.487±80.949 ng/L) (t=8.242, P<0.001). The blood fat showed no statistical difference between the two groups (P>0.05). According to Pearson correlation analysis, the serum Betatrophin level in cord blood had positive correlations with birth weight, lengh, ponderal index (PI) of neonates and triglyceride (TG) in cord blood (r=0.894, 0.632, 0.860, 0.767, P<0.001). There was negative correlation between serum betatrophin and adiponectin level in cord blood (r=-0.398, P<0.05). The serum Betatrophha level in cord blood was not correlated with Betatrophin in maternal blood, body mass before pregnancy and delivery, pre-pregnancy BMI or BMI increase during pregnancy (P>0.05). Conclusion: Alteration in serum Betatrophin is correlated with macrosomia. The Betatrophin level can reflect the status of feta1 development.

Key words： Betatrophin macrosomia blood fat ponderal index cord blood

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	ZHENG Junhu
	PAN Yicong
	KE Rushu
	CHEN Hong
	HU Xiaona
	WANG Dahua

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https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2019.02.008 OR https://xb.wmu.edu.cn/EN/Y2019/V49/I2/113

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