颈动脉支架置入术对颈动脉狭窄所致脑白质疏松与认知功能改变的影响

doi:10.3969/j.issn.2095-9400.2019.01.006

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Abstract Objective: To investigate the correlation between carotid artery stenosis and leukoaraiosis (LA) and cognitive impairment, and the changes of LA and cognitive function after carotid artery stenting (CAS). Methods: The study included 44 hospitalized patients with carotid artery stenosis greater than 70% which were confirmed by digital subtraction angiography from Zhoushan Hospital Affiliated to Wenzhou Medical University during August 2014 to August 2017. All the patients were divided into two groups, with 22 cases in both stenting group and the control group. The Cranial MRI examination was performed at the baseline and six-month follow-up. Before treatment, 1 month after treatment and 6 months after treatment, neuropsychological tests were performed, including Mini-Mental State Examination (MMSE) and Wechsler Adult Intelligence Scale-RC (WAIS-RC). The baseline characteristics and follow-up results were compared in each group. Results: After controlling other risk factors, the volume of LA lesions was still related to the degree of carotid artery stenosis (r=0.473, P<0.05), the score of MMSE was still related to the degree of carotid artery stenosis (r= -0.330, P<0.05). Compared with the control group, the volume of LA lesions and the score of MMSE were both significantly ameliorated in the stent implantation group after treatment (P<0.05). The score of WAIS-RC was significantly improved after operation compared with preoperative, mainly in the arithmetic, digit span, digit symbol, block design test. Conclusion: ①Carotid artery stenosis was related to LA and cognitive dysfunction. The more serious the stenosis is, the greater volume of LA lesions and the more severe of cognitive impairment. ②LA and cognitive function was ameliorated after CAS.

Key words： carotid artery stenosis leukoaraiosis cognition carotid artery stenting

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	ZHOU Lin
	SHEN Minhui
	SUN Maojun
	WANG Binda
	TANG Weiguo

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https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2019.01.006 OR https://xb.wmu.edu.cn/EN/Y2019/V49/I1/24

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