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| The preparation of hesperidin suppository and its quality evaluation |
| JIN Hui, LIN Jiale, WANG Chenxiang, ZHOU Ziye |
| Department of Pharmacy, the First Affilliated Hospital of Wenzhou Medical University, Wenzhou 325015, China |
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| Cite this article: |
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JIN Hui,LIN Jiale,WANG Chenxiang, et al. The preparation of hesperidin suppository and its quality evaluation[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2019, 49(1): 20-23.
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Abstract Objective: To prepare hesperidin suppository and establish a quality control method. Methods: Hesperidin was used as an active ingredient. Polyethylene glycol 400, polyethylene glycol 6000 and glycerol were chosen as substrates. Fusion method was applied to prepare the hesperidin suppository. The content uniformity, appearance, melting time and weight variation were evaluated. Results: The hesperidin suppository showed brown appearance and desirable hardness at room temperature. The content uniformity, weight variation and melting time of hesperidin suppository prepared by this method met the requirements of quality control. Conclusion: The hesperidin suppository prepared by this method meet the quality requirements of suppository and may be developed as a new formulation of hesperidin.
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