干扰SIRT7抑制甲状腺癌细胞的增殖、迁移和侵袭能力

doi:10.3969/j.issn.2095-9400.2019.01.003

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Abstract Objective: To study the effect of interfering SIRT7 on the proliferation, migration and invasion of thyroid cancer cell BCPAP in vitro. Methods: The stable strain of BCPAP interferred with SIRT7 was constructed by lentivirus, and the interference effect was verified at mRNA and protein levels. The effects of SIRT7 on the proliferation, migration and invasion of thyroid cancer BCPAP in vitro were studied by cell migration and cell invasion assay. Results: The stable cell line of BCPAP interfered with SIRT7 was successfully constructed, and after interfering SIRT7, the proliferation activity of BCPAP, the ability of scar healing and the ability of cell migration and invasion were significantly decrease and showed statistical difference (P<0.05). Conclusion: SIRT7 might play a role as an oncogene in thyroid cancer and could be considered a potential therapeutic target against thyroid cancer.

Key words： thyroid neoplasms oncogenes sirtuin SIRT7

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	Chen Xiaoxi
	Chen Xuxu
	Lin Jiahao
	Chen Jicai
	Huang Guoyu

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https://xb.wmu.edu.cn/EN/10.3969/j.issn.2095-9400.2019.01.003 OR https://xb.wmu.edu.cn/EN/Y2019/V49/I1/11

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