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| Research on accelerated healing of skin wounds of diabetic ulceration by curcumol ointment |
School of Pharmacy, Wenzhou Medical University, Wenzhou, 325035
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ZHOU Jie,ZHU Yanlin,DONG Jianyong, et al. Research on accelerated healing of skin wounds of diabetic ulceration by curcumol ointment[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(6): 411-.
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Abstract Objective: To study the effect of topical administration of curcumol ointment on the wound healing process in diabetic rats. Methods: The study was conducted using male Sprague Dawley rats which were separated into three groups: diabetic rats receiving control cream, diabetic rats receiving 5% curcumol ointment, and diabetic rats receiving 10% curcumol ointment. Two 1.8 cm diameter cutaneous wounds were then created at the dorsal regions of each rats. Wound healing was assessed by rate of wound closure estimation, and histological studies on the 3, 7, 14 and 21 d after wounding. Results: Curcumol ointment treatment enhanced the wound healing process by increasing rate of wound closure significantly compared to the control group (P<0.05). Histological observation also showed the 10% curcumol ointment treated groups significantly promoted the number of capillaries, improved the collagen synthesis, and increased the positive expressions of CD31 and TGF-β1. Conclusion: Curcumol ointment administrations can improve the speed and quality of skin wound healing.which could provide theoretical foundation for clinical treatment of diabetic ulcer.
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Received: 02 September 2013
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